ArticleHearing research2022
Cochlear Amplification in the Short-Wave Region by Outer Hair Cells changing Organ-of-Corti area to Amplify the Fluid Traveling Wave.
Article in Hearing research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Displacement gradients in the lateral region of the organ of Corti dissipate power in the cochlea.Biophysical journal · 2026Article
- Broadband amplification of organ of Corti vibrations in the mouse cochlear apex.bioRxiv : the preprint server for biology · 2026Article
- An alternative pathway for delivery of power by outer hair cells to cochlear traveling waves.Hearing research · 2026Article
- Study of organ of Corti motion in the guinea pig base including differential analysis of internal motion.Hearing research · 2025Article
- Longitudinal Vibrations in the Organ of Corti are Limited to Its Core.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Theoretical and experimental study on traveling wave propagation characteristics of artificial basilar membrane.Scientific reports · 2025Article
- The cortilymph wave: Its relation to the traveling wave, auditory-nerve responses, and low-frequency downward glides.Hearing research · 2025Review
- Narrow elliptical motion at the outer hair cell-Deiters' cell junction explains disparate features of uniaxial displacement measurements.Hearing research · 2025Article
- The Reduced Cortilymph Flow Path in the Short-Wave Region Allows Outer Hair Cells to Produce Focused Traveling-Wave Amplification.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Low-side and multitone suppression in the base of the gerbil cochlea.Biophysical journal · 2025Article
- Outer hair cells stir cochlear fluids.eLife · 2025Article
- Corti Fluid Is a Medium for Outer Hair Cell Force Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Visualizing motions within the cochlea's organ of Corti and illuminating cochlear mechanics with optical coherence tomography.Hearing research · 2025Review
- Outer hair cells stir cochlear fluids.bioRxiv : the preprint server for biology · 2024Article
- The Origin Along the Cochlea of Otoacoustic Emissions Evoked by Mid-Frequency Tone Pips.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Asymmetric vibrations in the organ of Corti by outer hair cells measured from excised gerbil cochlea.Communications biology · 2024Article
- Regional differences in cochlear nonlinearity across the basal organ of Corti of gerbil: Regional differences in cochlear nonlinearity.Hearing research · 2024Article
- Intracochlear overdrive: Characterizing nonlinear wave amplification in the mouse apex.The Journal of the Acoustical Society of America · 2023Article
- Otoacoustic emissions reveal the micromechanical role of organ-of-Corti cytoarchitecture in cochlear amplification.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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Abstract
Many details of the operation of the mammalian cochlea are known, but how they all work together to produce cochlear amplification is not understood. Outer-hair-cell (OHC) motility produces two kinds of amplification: non-propagating amplification (NPA) that is from local OHCs, and traveling-wave amplification (TWA) that increases basilar-membrane (BM) motion. Proposed here are a series of hypotheses that provide a new explanation, the "OoC-area-pump", for TWA: (1) In the short-wave region OHC vibrations cause cyclic longitudinal motion of fluid in the organ of Corti (OoC) and peri-Deiters-cell tissue, (2) the longitudinal motion changes the local OoC area, which (3) by reticular-lamina (RL) movement drives the fluid in scala media in a way that amplifies the fluid-pressure traveling wave. (4) At the NPA-TWA changeover frequency, an abrupt change in the OoC frequency-wavenumber relationship is due to positive feedback between TWA and the mode of cochlear motion that is dominant, aided by focusing of the pressure traveling wave. It is hypothesized that OoC radial expansion and radial force from the Deiters-cell phalangeal process act to advance RL and/or lateral-compartment phase. Finally, it is hypothesized that human and lab-animal frequency tuning have similar bandwidths in distance along the cochlea because their traveling-wave wavelengths are similar in the corresponding short-wave regions. Experiments are needed to test these hypotheses and to determine for TWA whether the OoC-area-pump hypothesis replaces or supplements the "OHCs-act-on-BM" hypothesis. Several tests are outlined that can be done with current methodology. A key step in the evolution of mammalian hearing was the development of the complex OoC anatomy, including Deiters cells and OoC fluid spaces that allow local wide-band NPA to produce TWA that enables small local increments of gain to accumulate in the traveling wave and sharpen tuning.
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