ArticleSmart medicine2024
Microfluidic 3D printing hydrogels based on fish liver decellularized extracellular matrix for liver regeneration.
Article in Smart medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A xenogeneic developmental matrix hydrogel with MnOBioactive materials · 2026Article
- Engineering biomimetic coronary artery equivalents for Kawasaki disease modeling and drug screening.Materials today. Bio · 2026Article
- Adipose-derived extracellular vesicles miR-423-5p targets SMAD3 to reverse endometrial fibrosis in a porcine model of intrauterine adhesion: insights from single-cell sequencing.Materials today. Bio · 2026Article
- Berberine-Mangiferin Self-Assembled Carrier-Free Hydrogel Suppresses NETosis for Augmented Psoriasis Treatment.Advanced healthcare materials · 2026Article
- Freeze-Derived Microporous Biomaterials for Tissue Engineering Applications.Smart medicine · 2026Review
- Advances in Decellularization of Fish Wastes for Extracellular Matrix Extraction in Sustainable Tissue Engineering and Regenerative Medicine.Bioengineering (Basel, Switzerland) · 2026Review
- Gelatin-based porous scaffolds: design concepts, production, and applications in precision regenerative medicine.Materials today. Bio · 2026Review
- Engineered Inner Ear Drug Delivery Systems for Hearing Loss Treatment.Research (Washington, D.C.) · 2026Review
- Polydopamine-Integrated Porcine Small Intestine Decellularized Extracellular Matrix Hydrogel Microparticles for Wound Healing.Smart medicine · 2025Article
- Permeable Hydrogel Encapsulated Osteosarcoma-on-a-Chip for High-Throughput Multi-Drugs Screening.Smart medicine · 2025Article
- Self-Organized Vascularized Hepatic Organoids in Microcapsules for Liver Regeneration.Research (Washington, D.C.) · 2025Article
- Microfluidic 3D printing hydrogels based on fish liver decellularized extracellular matrix for liver regeneration.Smart medicine · 2024Article
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Authors and funding
9 authors.
Funding
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Abstract
Liver tissue engineering offers potential in liver transplantation, while the development of hydrogels for scalable scaffolds incorporating natural components and effective functionalities is ongoing. Here, we propose a novel microfluidic 3D printing hydrogel derived from decellularized fish liver extracellular matrix for liver regeneration. By decellularizing fish liver and combining it with gelatin methacryloyl, the hydrogel scaffold retains essential endogenous growth factors such as collagen and glycosaminoglycans. Additionally, microfluidic-assisted 3D printing technology enables precise modulation of the composition and architecture of hydrogels to fulfill clinical requirements. Benefiting from the natural source of materials, the hydrogels exhibit excellent biocompatibility and cellular proliferation capacity for incorporating induced pluripotent stem cell-derived hepatocytes (iPSC-heps). Furthermore, the macroscopic architecture and biomechanical environment of hydrogels foster optimal functional expression of iPSC-heps. Importantly, post-transplantation, the hydrogels significantly enhance survival rates and liver function in mice with acute liver failure, promoting liver regeneration and repair. These findings suggest that microfluidic 3D printed hydrogels represent promising candidates for liver transplantation and functional recovery.
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