Evidence map›Paper›PMID 39776548›Full record

ArticleJournal of otology2024

Exploring the efficacy of (R)-PFI-2 hydrochloride in mitigating noise-induced hearing loss by targeting NLRP3 inflammasome and NF-κB pathway to reduce inner ear inflammation.

Dawei Ren, Xuemin Chen, Hongdong Liu, Menghua Li, Liting Zheng, Pan Yong, Mohe Huang, Xi Shi, Yice Xu, Shujin Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of otology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dawei RenDepartment of Otorhinolaryngology, the First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Xuemin ChenDepartment of Otorhinolaryngology, No. 971 Hospital of People's Liberation Army Navy, Qingdao, 266000, Shandong Province, China.
Hongdong LiuSenior Department of Otolaryngology-Head & Neck Surgery, Chinese PLA General Hospital, National Clinical Research Center for Otolaryngologic Diseases, State Key Lab of Hearing Science, Ministry of Education, Beijing Key Lab of Hearing Impairment Prevention and Treatment, Beijing, 100083, China.
Menghua LiArtificial Auditory Laboratory of Jiangsu Province, Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China.
Liting ZhengArtificial Auditory Laboratory of Jiangsu Province, Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China.
Pan YongArtificial Auditory Laboratory of Jiangsu Province, Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China.
Mohe HuangKey Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, Hainan Provine, China.
Xi ShiArtificial Auditory Laboratory of Jiangsu Province, Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China.
Yice XuDepartment of Otolaryngology-Head and Neck Surgery, The Central Hospital of Xiaogan, Xiaogan, 432000, Hubei, China.
Shujin ChenENT Department, The People's Hospital of Rongchang District, Chongqing, 402460, China.
Yan ZhangDepartment of Otorhinolaryngology, the First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Wei ZhuDepartment of Otorhinolaryngology, the First Hospital of Jilin University, Changchun, 130021, Jilin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noise-induced hearing loss (NIHL) is primarily driven by inflammatory processes within the cochlea, where noise exposure triggers the activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, leading to an inflammatory cascade. The interaction between increased NLRP3 expression and NF-κB activity can further amplify cochlear inflammation. Our findings reveal that (R)-PFI-2 hydrochloride, a selective inhibitor of the SETD7 enzyme, effectively inhibits the activation of the cochlear NF-κB pathway, suppresses the release of pro-inflammatory factors, and prevents inflammasome assembly. This intervention disrupts the perpetuating cycle of inflammation, thereby alleviating damage to cochlear hair cells attributed to acoustic trauma. Consequently, (R)-PFI-2 hydrochloride emerges as a promising pharmacological candidate for NIHL, targeting and moderating the excessive immune and inflammatory responses implicated in the pathology of hearing loss.

Indexed as

NF-κBNIHLNLRP3(R)-PFI-2 hydrochlorideSETD7

Identifiers

PMID39776548
PMCPMC11701333

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.