Evidence map›Paper›PMID 39776388›Full record

ArticleJournal of assisted reproduction and genetics2025

The influence of seminal microbiota on human testicular steroidogenesis: a prospective study.

Rossella Cannarella, Roberto Curto, Rosita A Condorelli, Agata Grillo, Antonio Aversa, Aldo E Calogero, Sandro La Vignera

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Article in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rossella CannarellaDepartment of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123, Catania, Italy. rossella.cannarella@unict.it.ORCID http://orcid.org/0000-0003-4599-8487
Roberto CurtoDepartment of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123, Catania, Italy.
Rosita A CondorelliDepartment of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123, Catania, Italy.
Agata GrilloLabogen (Specialized Human Genetics Laboratory), 95124, Catania, Italy.
Antonio AversaDepartment of Experimental and Clinical Medicine, Magna Græcia University, 88100, Catanzaro, Italy.
Aldo E CalogeroDepartment of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123, Catania, Italy.
Sandro La VigneraDepartment of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123, Catania, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePreclinical evidence has demonstrated that gut microbiota composition can influence steroid hormone biosynthesis and spermatogenesis. This study aims to investigate the association of seminal microbiota and testicular steroidogenesis. PATIENTS AND

methodsOne hundred adult eugonadal men were consecutively enrolled. The seminal concentration of Lactobacilli, anaerobic and facultative bacteria, as well as serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and total testosterone (TT) were evaluated. Unadjusted and adjusted multi-regression models were built to evaluate the relationship between seminal Lactobacilli, anaerobic and facultative bacteria, and Lactobacilli/total bacteria ratio, and serum LH, FSH, and TT. The concentrations of seminal Lactobacilli, anaerobic, and facultative bacteria predictive of serum TT values in the lowest quartile (< 3.8 ng/mL) were calculated.

resultsTT levels were weakly and positively correlated with seminal Lactobacillus concentration (r = 0.33; p = 0.001), with seminal Lactobacilli/total bacteria ratio (r = 0.89; p < 0.001), and negatively with anaerobic and facultative bacteria (r = - 0.69; p < 0.001). Opposite correlations were found for gonadotropin concentrations. These data persisted after adjustment for confounding factors. Seminal concentration of Lactobacilli ≤ 0.1 × 10

conclusionA relationship between the composition of the seminal microbiota and testicular steroidogenesis seems to exist. The mechanisms underlying this association are still unknown.

Indexed as

MicrobiotaSemenSpermatogenesisTestisTestosteroneAdultFollicle Stimulating HormoneHumansLactobacillusLuteinizing HormoneMaleProspective StudiesFollicle Stimulating HormoneLuteinizing HormoneTestosteroneAnaerobic bacteriaFacultative bacteriaLactobacilliSemina microbiotaTestosterone

Identifiers

PMID39776388
PMCPMC11950476

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.