Evidence map›Paper›PMID 39776370›Full record

ArticleBiochemical genetics2026

Single-Nucleotide Polymorphisms in MMP3, TIMP1, and MTR Genes are Associated With Delayed Deciduous Tooth Eruption.

Barbara Alves Fonseca, Thaís de Oliveira Fernandes, Dalila Ferreira Silvano de Moura, Caio Luiz Bittencourt Reis, Erika Calvano Küchler, Flares Baratto-Filho, Leonardo Santos Antunes, Lívia Azeredo Alves Antunes

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Article in Biochemical genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Barbara Alves FonsecaPosgraduate Program in Dentistry, Institute of Health Sciences, Fluminense Federal University, Nova Friburgo, RJ, Brazil.ORCID http://orcid.org/0000-0002-2328-315X
Thaís de Oliveira FernandesPosgraduate Program in Dentistry, Institute of Health Sciences, Fluminense Federal University, Nova Friburgo, RJ, Brazil.ORCID http://orcid.org/0000-0002-1919-543X
Dalila Ferreira Silvano de MouraSchool of Biomedicine, Institute of Health Sciences, Fluminense Federal University, Nova Friburgo, RJ, Brazil.ORCID http://orcid.org/0009-0008-8047-974X
Caio Luiz Bittencourt ReisDepartment of Orthodontics, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-0606-1632
Erika Calvano KüchlerDepartment of Orthodontics, Medical Faculty, University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0001-5351-2526
Flares Baratto-FilhoSchool of Dentistry, Tuiuti University From Paraná, Curitiba, Paraná, Brazil.ORCID http://orcid.org/0000-0002-5649-7234
Leonardo Santos AntunesPosgraduate Program in Dentistry, Institute of Health Sciences, Fluminense Federal University, Nova Friburgo, RJ, Brazil.ORCID http://orcid.org/0000-0002-2115-6958
Lívia Azeredo Alves AntunesPosgraduate Program in Dentistry, Institute of Health Sciences, Fluminense Federal University, Nova Friburgo, RJ, Brazil. liviaazeredo@gmail.com.ORCID http://orcid.org/0000-0002-8432-0815

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior code 001Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/201.337/2022The National Council for Scientific and Technological Development 102385/2024-6The National Council for Scientific and Technological Development (CNPq) IC210459 /IC220334/IC230584
6 · The paper itself

Abstract

To analyze whether the single-nucleotide polymorphisms (SNPs) in Matrix metalloproteinases 2, 3, and 9 (MMP2, MMP3, and MMP9), Tissue Inhibitor of Metalloproteinases 1 and 2 (TIMP1 and TIMP2), methionine synthase (MTR) and methionine synthase reductase (MTRR) influence delayed deciduous tooth eruption (DDTE). This cross-sectional study included 1060 biologic unrelated children (aged between 6 and 36 months) of both sexes, selected from 25 public schools in Nova Friburgo, Rio de Janeiro, Brazil. Oral examination was conducted and DDTE was defined by the absence of gingival eruption according to a chronology based on the Brazilian population. Genotyping of selected SNPs (rs243847, rs52261, rs17576, rs4898, rs7501477, rs1805087, and rs1801394) was performed using TaqMan real-time PCR with genomic DNA extracted from buccal cells. The association between genotypes and DDTE was evaluated using univariate and multivariate analyses (p < 0.05). A total of 224 children and caregivers were included after the eligibility criteria. The heterozygous genotype for the SNPs MTR (rs11805087) was associated with DDTE in both the univariate (p = 0.004) and multivariate (p < 0.001) codominant models, as well as in the univariate (p = 0.010) and multivariate (p = 0.001) recessive models. TIMP1 (rs4898) and MMP3 (rs522616) were associated with DDTE only in the univariate model (p < 0.05). The SNPs in MTR (rs11805087), MMP3 (rs522616) and TIMP (rs4898) genes are associated with DDTE. The factors affecting the chronology of deciduous tooth eruption has been insufficiently studied. This article brings novel knowledge regarding the role of genetics polymorphisms on timing variation of deciduous tooth eruption. Understanding the factors that impact tooth eruption is crucial for the fields of pediatric dentistry and orthodontics.

Indexed as

5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseMatrix Metalloproteinase 3Polymorphism, Single NucleotideTissue Inhibitor of Metalloproteinase-1Tooth, DeciduousTooth EruptionChild, PreschoolCross-Sectional StudiesFemaleFerredoxin-NADP ReductaseGenotypeHumansInfantMaleOxidoreductases Acting on CH-CH Group Donors5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseFerredoxin-NADP ReductaseMatrix Metalloproteinase 3methionine synthase reductaseMMP3 protein, humanMTR protein, humanOxidoreductases Acting on CH-CH Group DonorsTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1Deciduous toothDelayed tooth eruptionGenetic polymorphismSingle-nucleotide polymorphismTooth eruption

Identifiers

PMID39776370

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