Evidence map›Paper›PMID 39776351›Full record

ArticleChemistryOpen2025

Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents.

Secret P Els, Kimberleigh B Govender, Mxolisi K Sokhela, Nilay Bhatt, Nakita Reddy, Hendrik G Kruger, Per I Arvidsson, Hendra Gunosewoyo, Thavendran Govender, Tricia Naicker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Secret P ElsDiscipline of Pharmaceutical Sciences, Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban, 4000, South Africa.
Kimberleigh B GovenderDiscipline of Pharmaceutical Sciences, Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban, 4000, South Africa.
Mxolisi K SokhelaDiscipline of Pharmaceutical Sciences, Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban, 4000, South Africa.
Nilay BhattDiscipline of Pharmaceutical Sciences, Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban, 4000, South Africa.
Nakita ReddyDiscipline of Pharmaceutical Sciences, Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban, 4000, South Africa.ORCID 0000-0003-4428-2241
Hendrik G KrugerDiscipline of Pharmaceutical Sciences, Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban, 4000, South Africa.ORCID 0000-0003-0606-2053
Per I ArvidssonDiscipline of Pharmaceutical Sciences, Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban, 4000, South Africa.ORCID 0000-0002-9453-6812
Hendra GunosewoyoCurtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, Perth, WA 6102, Australia.ORCID 0000-0003-3897-1948
Thavendran GovenderDepartment of Chemistry, University of Zululand, Private Bag X1001, KwaDlangezwa, 3886, South Africa.ORCID 0000-0003-2511-2503
Tricia NaickerDiscipline of Pharmaceutical Sciences, Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Durban, 4000, South Africa.ORCID 0000-0002-7134-6258

Funding

South African National Research Foundation 120419South African National Research Foundation 137961South African National Research Foundation 145774
6 · The paper itself

Abstract

An efficient microwave-assisted synthesis route for novel oxazolidinone analogues has been developed. The general synthesis of these compounds began with an L-proline-mediated three-component Mannich reaction between commercially available 3-fluoro-4-morpholinoaniline, aqueous formaldehyde and α-hydroxyacetone. This was followed by a one-step cyclisation to form the core structure of oxazolidinone antibiotics which was subsequently derivatized. The novel compounds were evaluated for their antibacterial activity against M. smegmatis. One of the novel oxazolidinone derivatives 18 a1 produced a MIC of 8 mg/L, comparable with the commercial Rifampicin. The methodology is a useful addition to the field since it can make highly sought-after oxazolidinone derivatives, using cheaper, less harsh commercially available reagents, in a short time and one pot.

Indexed as

Anti-Bacterial AgentsOxazolidinonesCyclizationMicrobial Sensitivity TestsMicrowavesAnti-Bacterial AgentsOxazolidinones

Identifiers

PMID39776351
PMCPMC12256933

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.