Evidence map›Paper›PMID 39776311›Full record

Trial reportJournal of diabetes investigation2025

Effects of high-intensity interval walking training on muscle strength, walking ability, and health-related quality of life in people with diabetes accompanied by lower extremity weakness: A randomized controlled trial.

Yasuko Ichihara, Hiroyasu Mori, Motomu Kamada, Tetsuya Matsuura, Koichi Sairyo, Mizusa Hyodo, Rie Tsutsumi, Hiroshi Sakaue, Ken-Ichi Aihara, Makoto Funaki and 2 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of diabetes investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yasuko IchiharaDiabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
Hiroyasu MoriDiabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.ORCID https://orcid.org/0000-0002-0557-931X
Motomu KamadaDivision of Rehabilitation, Tokushima University Hospital, Tokushima, Japan.
Tetsuya MatsuuraDepartment of Rehabilitation Medicine, Tokushima University Hospital, Tokushima, Japan.
Koichi SairyoDepartment of Orthopedic Surgery, Tokushima University Graduate School of Medicine, Tokushima, Japan.
Mizusa HyodoDepartment of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Rie TsutsumiDepartment of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Hiroshi SakaueDepartment of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Ken-Ichi AiharaDepartment of Community Medicine and Medical Science, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.ORCID https://orcid.org/0000-0001-8906-0920
Makoto FunakiDiabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
Akio KurodaDiabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.ORCID https://orcid.org/0000-0003-2147-6844
Munehide MatsuhisaDiabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.ORCID https://orcid.org/0000-0003-4624-939X

Funding

Japan Association for Diabetes Education and Care 2021-ELD-004
6 · The paper itself

Abstract

AIMS/

introductionThis study examined the effects of high-intensity interval walking training (IWT) compared to moderate-intensity continuous walking training (CWT) on muscle strength, walking ability, and health-related quality of life (QOL) in people with diabetes accompanied by lower extremity weakness. MATERIALS AND

methodsPeople with diabetes accompanied by low isometric knee extensor strength using a simple manual dynamometer (n = 50) were screened and randomly divided into 2 groups: CWT (n = 25) and IWT (n = 25). Both groups were instructed by a physical therapist to perform walking training with the goal of 120 min/week over a 5-month period. The primary outcome, mean change of isometric knee extensor strength, and secondary outcomes, such as gait speed and health-related QOL, were measured at baseline and the end of the intervention.

resultsAt the end of the intervention, there was no significant difference in the degree of change in isometric knee extension strength between the two groups. However, there was a significant increase in changes in gait speed and physical QOL in the IWT group (gait speed, P < 0.01; physical QOL, P < 0.05).

conclusionsThe present study showed that IWT for people with diabetes accompanied by lower extremity weakness did not improve knee extension muscle strength compared to CWT but did improve walking ability and physical QOL.

Indexed as

High-Intensity Interval TrainingLower ExtremityMuscle StrengthMuscle WeaknessQuality of LifeWalkingAgedFemaleHumansMaleMiddle AgedDiabetesHigh‐intensity interval fast walking trainingMuscle weakness

Identifiers

PMID39776311
PMCPMC11970289

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.