ArticleOdontology2025
Transcriptional regulation of human follicular dendritic cell-secreted protein gene by interleukin-6.
Article in Odontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Multi-omics analysis identifies the unique high-FDCSP basal cells in triple-negative breast cancer.Experimental biology and medicine (Maywood, N.J.) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Follicular dendritic cell-secreted protein (FDC-SP) is produced by follicular dendritic cells, periodontal ligament and junctional epithelium (JE). JE exists immediately apical to the bottom of the pocket and binds enamel with hemidesmosomes to protect the periodontium from bacterial infection. To analyze the transcriptional regulation of the FDC-SP gene by interleukin-6 (IL-6), we performed real-time PCR, Western blotting, immunofluorescence, luciferase (LUC) assays, gel mobility shift and chromatin immunoprecipitation (ChIP) assays using Ca9-22 and Sa3 gingival epithelial cells. IL-6 increased FDC-SP mRNA and protein levels at 3-24 h. IL-6 increased LUC activities of the LUC constructs containing FDC-SP gene promoter sequences from -116 to -717 bp upstream from the transcriptional start site. IL-6 induced LUC activities of -345FDCSP were inhibited by protein kinase A, tyrosine kinase, mitogen-activated protein kinase kinase, phosphoinositide 3-kinase, signal transducer, activator of transcription 3 (STAT3) and glycoprotein 130 inhibitors. Gel shift and ChIP assays showed that IL-6 induced Yin Yang1 (YY1), GATA binding protein (GATA), CCAAT/enhancer-binding protein (C/EBP) β, phosphorylated STAT3 (p-STAT3) binding to YY1, GATA, C/EBP2, C/EBP3 and GAS2-3 elements. These results indicate that IL-6 induces FDC-SP gene transcription YY1, GATA, C/EBP2, GAS2-3 and C/EBP3 elements in the human FDC-SP gene promoter, and suggesting that FDC-SP may be involved in the defense against JE in periodontium during the progression of periodontitis.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.