ArticleSleep & breathing = Schlaf & Atmung2025
The effect of continuous positive airway pressure therapy on early atherosclerosis in patients with severe obstructive sleep apnea-hypopnea syndrome.
Article in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- ZIKV NS3 disrupts Nrf2-mediated antioxidant defense and drives vascular smooth muscle cell damage and vascular dysfunction.Zoological research · 2026Article
- Beyond the Usual Suspects: A Narrative Review of High-Yield Non-Traditional Risk Factors for Atherosclerosis.Journal of clinical medicine · 2026Review
- [Analysis the influencing factors and risk warning of the therapeutic efficacy of multi plane low temperature plasma radiofrequency ablation for OSAHS].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Article
- Continuous positive airway pressure therapy, obstructive sleep apnea-hypopnea syndrome and atherosclerosis: the effect of timing of carotid intima-media thickness measurement during cardiac cycle.Sleep & breathing = Schlaf & Atmung · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeObstructive sleep apnea-hypopnea syndrome (OSAHS) is the most common sleep-related breathing disorder. Longer term, repeated episodes of hypercapnia and hypoxemia during sleep are associated with inflammatory and atherosclerosis-related factors. The aim of this study was to explore the effect of continuous positive airway pressure (CPAP) therapy on cerebral vasoreactivity and early atherosclerosis in patients with severe OSAHS.
methodsForty-one patients with severe OSAHS were enrolled. The mean follow-up time was 39.8 ± 9.1 months. Cardiovascular risk factors were assessed, and laboratory tests, carotid artery intima-media thickness (CIMT) measurement and cerebrovascular reserve capacity (CRC) measurement were performed. After the baseline examination, 28 patients received CPAP therapy (treated group), which was not available for 13 patients (untreated group). Parameters were compared before and after treatment, between treated and untreated patients.
resultsCardiovascular risk factors, baseline polysomnographic parameters, laboratory values, CIMT and CRC of the two groups were similar at baseline. At the follow-up, CRC did not differ between the two groups, but CIMT was significantly lower in the treated group than in the untreated group (0.73 ± 0.11 mm vs. 0.84 ± 0.21 mm, p = 0.027). The CIMT of both groups increased significantly during the follow-up period (from 0.65 ± 0.11 mm to 0.73 ± 0.11 mm in the treated group, and from 0.69 ± 0.11 mm to 0.84 ± 0.21 mm in the untreated group), but the increase in the treated group was smaller than in the untreated group (0.09 ± 0.09 mm vs. 0.15 ± 0.15 mm).
conclusionIn patients with severe OSAHS, CPAP treatment significantly reduced the progression of CIMT.
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