Evidence map›Paper›PMID 39776059›Full record

ReviewActa neurologica Belgica2025

Advancements in diagnosing Post-concussion Syndrome: insights into epidemiology, pathophysiology, neuropathology, neuroimaging, and salivary biomarkers.

Ioannis Mavroudis, Foivos Petridis, Alin Ciobica, Fatima Zahra Kamal, Manuela Padurariu, Dimitrios Kazis

Abstract readReview
PubMed Publisher
In one paragraph

Review in Acta neurologica Belgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ioannis MavroudisDepartment of Neuroscience, Leeds Teaching Hospitals, NHS Trust, Leeds, UK.
Foivos PetridisThird Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Alin CiobicaDepartment of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, Bd. Carol I nr. 20A, Iasi, 700505, Romania.
Fatima Zahra KamalLaboratory of Physical Chemistry of Processes, Faculty of Sciences and Techniques, Hassan First University, B.P. 539, Settat, 26000, Morocco. fatimzahra.kamal@gmail.com.
Manuela PadurariuSocola Institute of Psychiatry, Șoseaua Bucium 36, Iași, 700282, Romania.
Dimitrios KazisThird Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-Concussion Syndrome (PCS) represents a complex constellation of symptoms that persist following a concussion or mild traumatic brain injury (mTBI), with significant implications for patient care and outcomes. Despite its prevalence, diagnosing PCS presents considerable challenges due to the subjective nature of symptoms, the absence of specific diagnostic tests, and the overlap with other neurological and psychiatric conditions. This review explores the multifaceted diagnostic challenges associated with PCS, including the heterogeneity of symptom presentation, the limitations of current neuroimaging techniques, and the overlap of PCS symptoms with other disorders. We also discuss the potential of emerging biomarkers and advanced imaging modalities to enhance diagnostic accuracy and provide a more objective basis for PCS identification. Additionally, the review highlights the importance of a multidisciplinary approach in the diagnosis and management of PCS, integrating clinical evaluation with innovative diagnostic tools to improve patient outcomes. Through a comprehensive analysis of current practices and future directions, this review aims to shed light on the complexities of PCS diagnosis and pave the way for improved strategies in the identification and treatment of this condition.

Indexed as

NeuroimagingPost-Concussion SyndromeSalivaBiomarkersHumansBiomarkersBiomarkersDiagnostic challengesMild traumatic brain Injury (mTBI)Multidisciplinary approachNeuroimaging techniquesPost-concussion Syndrome (PCS)

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.