ArticleAging clinical and experimental research2025
Global, regional, and national burden of malignant neoplasm of bone and articular cartilage in adults aged 65 years and older, 1990-2021: a systematic analysis based on the global burden of disease study 2021.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety comparison of small molecule anti-angiogenic drugs in the treatment of bone and soft tissue sarcomas : a network meta-analysis.BMC cancer · 2025Pooled it
- Emerging Nanocarrier Strategies for Optimized Drug Delivery in the Treatment of Primary Bone Cancer.Oncology research · 2026Review
- Global to local burdens, inequalities, and achievable frontiers of child and adolescent malignant neoplasm of bone and articular cartilage across 953 countries and sublocations, 1980-2040, with deep learning-based forecasts.Journal of orthopaedic translation · 2026Article
- Letter to the Editor: "Global, regional, and national burden of malignant neoplasm of bone and articular cartilage in adults aged 65 years and older, 1990-2021: a systematic analysis based on the global burden of disease study 2021".Aging clinical and experimental research · 2025Article
- Burden and projections of malignant neoplasm of bone and articular cartilage in China: an analysis for the global burden of disease study 2021.BMC musculoskeletal disorders · 2025Article
- Advancing bone tumor detection in older adults: the impact of AI-enhanced medical imaging.Frontiers in medicine · 2025Review
- The burden and trend prediction of atrial fibrillation and flutter associated with lead exposure: insights from the global burden of disease study 2021.Frontiers in cardiovascular medicine · 2025Article
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8 authors.
Funding
Abstract
backgroundThis study aims to delineate the global, regional, and national burden of malignant neoplasms of bone and articular cartilage (MNBAC) among individuals aged 65 years and older from 1990 to 2021, stratified by age, sex, and sociodemographic index (SDI).
methodsWe harnessed data from the Global Burden of Disease Study 2021 to evaluate the prevalence, incidence, mortality, and disability-adjusted life years (DALYs) associated with MNBAC among individuals aged 65 years and older across 204 countries and territories between 1990 and 2021. The socio-demographic Index (SDI) served as a metric to examine the influence of socioeconomic development on the burden of MNBAC. Furthermore, joinpoint regression analysis was employed to identify the years marked by the most significant temporal changes over the study period.
resultsIn 2021, an estimated 163,561 prevalent cases of MNBAC were recorded among individuals aged ≥ 65 years, alongside 28,100 newly diagnosed cases, 27,588 deaths, and 508,202 DALYs. The age-standardized rates per 100,000 population were 21.30 for prevalence, 3.69 for incidence, 3.66 for mortality, and 65.85 for DALYs. Notably, Cuba reported the highest prevalence rate (42.42), while the Philippines exhibited the greatest DALY burden (161.78). Egypt demonstrated the highest incidence (7.44) and mortality rates (8.90). A significant inverse correlation was observed between age-standardized DALY rates and SDI across regions.
conclusionsThis analysis underscores the substantial global burden of MNBAC among older adults, accentuating the imperative for tailored public health interventions, alongside advancements in diagnostic and therapeutic approaches, particularly within resource-constrained settings.
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