Evidence map›Paper›PMID 39775898›Full record

ArticleEuropean radiology2025

Co-occurrence of bronchiectasis, airway wall thickening, and emphysema in Chinese low-dose CT screening.

Zhenhui Nie, Marleen Vonder, Maaike de Vries, Xiaofei Yang, Matthijs Oudkerk, Dirk-Jan Slebos, Zhaoxiang Ye, Monique D Dorrius, Geertruida H de Bock

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Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Zhenhui NieDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Marleen VonderDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Maaike de VriesDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Xiaofei YangDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Matthijs OudkerkFaculty of Medical Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Dirk-Jan SlebosGroningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Zhaoxiang YeDepartment of Radiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Monique D DorriusDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Geertruida H de BockDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. g.h.de.bock@umcg.nl.ORCID http://orcid.org/0000-0003-3104-4471

Funding

Chinese Scholarship Council 202008450039Ministry of Science and Technology 2016YFE0103000Royal Netherlands Academy of Arts and Sciences PSA_SA_BD_01
6 · The paper itself

Abstract

objectiveTo assess the co-occurrence of incidental CT lung findings (emphysema, bronchiectasis, and airway wall thickening) as well as associated risk factors in low-dose CT (LDCT) lung cancer screening in a Chinese urban population.

methodsData from 978 participants aged 40-74 years from the Chinese NELCIN-B3 urban population study who underwent LDCT screening were selected. CT scans were reviewed for incidental lung findings: emphysema, bronchiectasis and airway wall thickness. Emphysema was defined in three ways (≥ trace, ≥ mild, or ≥ moderate) depending on severity. Participants were described and stratified by presence or absence of incidental lung findings. Logistic regression analyses were performed to examine the relationship between participant characteristics and CT findings.

resultsMean age was 61.3 years ± 6.8 and 533 (54.6%) were female. 48% of participants had incidental lung findings: 19.9% had emphysema (≥ mild), 9.2% had bronchiectasis, and 35.7% had airway wall thickening. Among 978 participants, 2.1% showed all three findings. Multivariable analysis showed that higher age (OR: 1.06; 95% CI: 1.04-1.08; p < 0.001), male sex (OR: 1.68; 95% CI: 1.14-2.47; p = 0.008) smoking history (OR: 1.76; 95% CI: 1.02-3.03; p = 0.04 for former smokers; OR: 2.45; 95% CI: 1.59-3.78; p < 0.001 for current smokers), and the presence of respiratory symptoms (OR: 1.42; 95% CI: 1.01-2.00; p = 0.04) were associated with the risk of having at least one incidental lung findings. When different definitions of emphysema were used, the results remained consistent.

conclusionIn a Chinese urban population undergoing LDCT lung cancer screening, 48% had at least one incidental CT lung finding, which was associated with higher age, male sex, questionnaire-based respiratory symptoms and smoking history. KEY POINTS: Question Reporting of incidental lung findings that indicate lung disease risk lacks consensus in the cancer screening setting and needs evidence of co-occurrence in general populations. Findings Almost half of the 978 participants had at least one incidental lung CT finding; these were associated with older age, male sex, respiratory symptoms, and smoking history. Clinical relevance Incidental lung findings and related risk factors are often observed in low-dose CT lung cancer screening, and careful consideration of their relevance should be given to their inclusion in future screenings.

Indexed as

BronchiectasisLung NeoplasmsPulmonary EmphysemaTomography, X-Ray ComputedAdultAgedChinaEast Asian PeopleFemaleHumansIncidental FindingsMaleMiddle AgedRadiation DosageRisk FactorsBronchial diseasesComputed tomographyEmphysemaIncidental findingsScreening

Identifiers

PMID39775898

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.