Evidence map›Paper›PMID 39775789›Full record

ArticleThe international journal of neuropsychopharmacology2024

The role of pallidal substance P and neurokinin receptors in the consolidation of spatial memory of rats.

Erika Kertes, László Péczely, Tamás Ollmann, Kristóf László, Beáta Berta, Veronika Kállai, Olga Zagorácz, Anita Kovács, Ádám Szabó, Zoltán Karádi and 1 more

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Article in The international journal of neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Erika KertesInstitute of Physiology, University of Pécs, Medical School, Pécs, Hungary.ORCID 0009-0007-2070-9112
László PéczelyInstitute of Physiology, University of Pécs, Medical School, Pécs, Hungary.ORCID 0000-0002-1754-5651
Tamás OllmannInstitute of Physiology, University of Pécs, Medical School, Pécs, Hungary.
Kristóf LászlóInstitute of Physiology, University of Pécs, Medical School, Pécs, Hungary.
Beáta BertaInstitute of Physiology, University of Pécs, Medical School, Pécs, Hungary.
Veronika KállaiInstitute of Physiology, University of Pécs, Medical School, Pécs, Hungary.
Olga ZagoráczInstitute of Physiology, University of Pécs, Medical School, Pécs, Hungary.
Anita KovácsInstitute of Physiology, University of Pécs, Medical School, Pécs, Hungary.
Ádám SzabóInstitute of Physiology, University of Pécs, Medical School, Pécs, Hungary.
Zoltán KarádiInstitute of Physiology, University of Pécs, Medical School, Pécs, Hungary.
László LénárdInstitute of Physiology, University of Pécs, Medical School, Pécs, Hungary.

Funding

Medical School PTE ÁOK KA-2020-06New National Excellence Program of the Ministry for Innovation and Technology ÚNKP-21-5-PTE-1333University of Pécs
6 · The paper itself

Abstract

backgroundThe tachykinin substance P (SP) facilitates learning and memory processes after its central administration. Activation of its different receptive sites, neurokinin-1 receptors (NK1Rs), as well as NK2Rs and NK3Rs, was shown to influence learning and memory. The basal ganglia have been confirmed to play an important role in the control of memory processes and spatial learning mechanisms, and as part of the basal ganglia, the globus pallidus (GP) may also be involved in this regulation. SP-immunoreactive fibers and terminals, as well as NK1Rs and NK3Rs, were shown to be present in the GP.

methodsThe present study aimed to examine whether the SP administered into the GP can influence spatial memory consolidation in the Morris water maze (MWM). Therefore, male Wistar rats received a post-trial microinjection of 0.4 µLf 10 ng SP, 100 ng SP, or vehicle solution. The possible involvement of pallidal NK1Rs and NK3Rs in the SP effects was also studied by applying WIN51708 for NK1R antagonism and SR142801 as a selective NK3R antagonist.

resultsOur results showed that the lower dose of SP significantly decreased escape latency on the second day compared to control animals, while the higher dose was ineffective. Prior treatment with the NK1R antagonist WIN51708 could not block, while the NK3R antagonist SR142801 inhibited the effects of SP on memory consolidation in the MWM.

conclusionsOur results are the first to demonstrate that SP improves consolidation of spatial memory in the GP, and this effect is mediated through NK3Rs but not NK1Rs.

Indexed as

Globus PallidusMemory ConsolidationReceptors, Neurokinin-1Receptors, Neurokinin-3Spatial MemorySubstance PAnimalsMaleMaze LearningNeurokinin-1 Receptor AntagonistsPiperidinesRatsRats, WistarNeurokinin-1 Receptor AntagonistsPiperidinesReceptors, Neurokinin-1Receptors, Neurokinin-3Substance Pglobus pallidusNK1 receptorsNK3 receptorsspatial memory consolidationsubstance P

Identifiers

PMID39775789
PMCPMC11757698

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.