Evidence map›Paper›PMID 39775736›Full record

ArticlePloS one2024

Community pharmacies: Key players in point-of-care diagnostics for STI screening in Africa.

Agnes N Kiragga, Annet Onzia, Vivian Nakate, Irene Bagaya, Evelyn Natuha, Emmanuel Mande, Olivia Kataike, Rosalind Parkes-Ratanshi, Matthew M Hamill, Yukari C Manabe

Abstract read
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Agnes N KiraggaResearch Department, Infectious Diseases Institute, Makerere College of Health Sciences, Kampala, Uganda.ORCID 0000-0002-0969-0699
Annet OnziaResearch Department, Infectious Diseases Institute, Makerere College of Health Sciences, Kampala, Uganda.
Vivian NakateResearch Department, Infectious Diseases Institute, Makerere College of Health Sciences, Kampala, Uganda.
Irene BagayaResearch Department, Infectious Diseases Institute, Makerere College of Health Sciences, Kampala, Uganda.
Evelyn NatuhaResearch Department, Infectious Diseases Institute, Makerere College of Health Sciences, Kampala, Uganda.
Emmanuel MandeResearch Department, Infectious Diseases Institute, Makerere College of Health Sciences, Kampala, Uganda.
Olivia KataikeResearch Department, Infectious Diseases Institute, Makerere College of Health Sciences, Kampala, Uganda.
Rosalind Parkes-RatanshiResearch Department, Infectious Diseases Institute, Makerere College of Health Sciences, Kampala, Uganda.ORCID 0000-0001-9297-1311
Matthew M HamillDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.ORCID 0000-0002-1277-819X
Yukari C ManabeDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

Funding

TrainingU54EB007958 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Matthew Hamill · 2007 to 2026
$34.6M
NIBIB NIH HHS U54 EB007958
6 · The paper itself

Abstract

backgroundSexually Transmitted Infections (STIs) rank in the top 5 disease categories for which adults in developing countries seek healthcare services. Community pharmacies offer clients convenience, proximity, extended opening hours, privacy, and efficiency, which could make them desirable locations for HIV and STI screening and treatment. We examined the feasibility of using point-of-care (POC) STI tests for screening HIV and other STIs at community pharmacies.

methodsWe conducted a prospective cohort study of persons seeking medication and other services at 18 purposively selected community pharmacies in Kampala, Uganda. Study participants comprised two broad categories: i) Symptomatic persons aged 18 years who presented with at least one STI sign or symptom and were purchasing treatment for themselves; ii) persons presenting with no STI symptom who had come to purchase any other medication, including family planning services such as emergency contraception. POC tests were used to test HIV, Chlamydia trachomatis (Ct), Neisseria gonorrhoeae (Ng), Trichomonas vaginalis (Tv), and Syphilis. Test results were returned on-site or via telephone within 48 to 72 hours. Descriptive statistics were used to estimate the prevalence of STIs.

resultsOf the 450 participants enrolled, 235 (52.2%) were symptomatic, 215 (47.8%) were asymptomatic, and 280 (62.2%) were females. STI testing was feasible, with an acceptability rate of 99.8%. 135 (30%) of participants had at least one STI; HIV prevalence was 39 (8.7%), Syphilis prevalence was 14 (3.1%), 50 (11.1%) tested positive for Ng, 39 (8.7%) were positive for Ct while. The prevalence of Tv was 25 (8.9%) (tested among women). A total of 107 (23.8%) participants had used an antibiotic in the preceding month.

conclusionOur research underscores the potentially pivotal role of community pharmacies in deploying POC diagnostics for STIs and antimicrobial stewardship by decreasing unnecessary antibiotic dispensation across Africa.

Indexed as

Mass ScreeningPoint-of-Care SystemsSexually Transmitted DiseasesAdolescentAdultChlamydia InfectionsFemaleHIV InfectionsHumansMaleMiddle AgedPharmaciesPoint-of-Care TestingProspective StudiesSyphilisUganda

Identifiers

PMID39775736
PMCPMC11684620

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.