Evidence map›Paper›PMID 39775678›Full record

ArticleThe Journal of physiology2026

Sex-specific differences in mortality and neurocardiac interactions in the Kv1.1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP).

Kelsey Paulhus, Praveen Kumar, Kelly Kneale, T Noah Hutson, Nicole M Gautier-Hall, Deng-Shan Shiau, Megan Watts, Krystle Trosclair, Hemangini A Dhaibar, Paari Dominic and 2 more

Abstract read
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kelsey PaulhusDepartment of Biological Sciences, Southern Methodist University, Dallas, TX, USA.ORCID https://orcid.org/0000-0002-4405-3900
Praveen KumarDepartment of Biological Sciences, Southern Methodist University, Dallas, TX, USA.ORCID https://orcid.org/0000-0002-9365-3929
Kelly KnealeDepartments of Translational Neuroscience and Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
T Noah HutsonDepartments of Translational Neuroscience and Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
Nicole M Gautier-HallDepartment of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA.ORCID https://orcid.org/0000-0002-4936-3043
Deng-Shan ShiauEpiFocus LLC, Scottsdale, AZ, USA.
Megan WattsDepartment of Internal Medicine, Section of Cardiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Krystle TrosclairDepartment of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Hemangini A DhaibarDepartment of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Paari DominicDepartment of Internal Medicine, Section of Cardiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Leonidas IasemidisDepartments of Translational Neuroscience and Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
Edward GlasscockDepartment of Biological Sciences, Southern Methodist University, Dallas, TX, USA.ORCID https://orcid.org/0000-0001-8702-2349

Funding

Biomarkers of SUDEP risk based on brain-heart-lungs network dynamicsR01NS129643 · NINDS · SOUTHERN METHODIST UNIVERSITY · PI GLASSCOCK, ALBERT E, JASSEMIDIS, LEONIDAS D · 2023 to 2025
$1.8M
Respiratory mechanisms of epilepsy with high risk of SUDEPR01NS100954 · NINDS · SOUTHERN METHODIST UNIVERSITY · PI GLASSCOCK, ALBERT E · 2017 to 2021
$1.6M
Neurocardiac mechanisms of epilepsy with high risk of SUDEPR01NS099188 · NINDS · SOUTHERN METHODIST UNIVERSITY · PI GLASSCOCK, ALBERT E · 2017 to 2020
$1.3M
HHS | National Institutes of Health (NIH) R01NS099188HHS | National Institutes of Health (NIH) R01NS100954HHS | National Institutes of Health (NIH) R01NS129643NINDS NIH HHS R01 NS099188NINDS NIH HHS R01 NS100954NINDS NIH HHS R01 NS129643
6 · The paper itself

Abstract

Sudden unexpected death in epilepsy (SUDEP) is a devastating complication of epilepsy with possible sex-specific risk factors, although the exact relationship between sex and SUDEP remains unclear. To investigate this, we studied Kcna1 knockout (Kcna1

Indexed as

BrainEpilepsyHeartKv1.1 Potassium ChannelSudden Unexpected Death in EpilepsyAnimalsDisease Models, AnimalFemaleHeart RateMaleMiceMice, Inbred C57BLMice, KnockoutSex CharacteristicsKcna1 protein, mouseKv1.1 Potassium Channelbrain‐heart interactionsepilepsyKv1.1sex differencesSUDEP

Identifiers

PMID39775678
PMCPMC13481012

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.