Oral Herpes Simplex Virus Mimicking Tongue Squamous cell Carcinoma in Von Hippel-Lindau Patient: A Case Image.

Maryann Zhao, Regan C Manayan, Michiya Nishino, Ernest D Gomez

Abstract readCase Reports

In one paragraph

Article in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Maryann ZhaoDepartment of Otolaryngology - Head and Neck Surgery, Harvard Medical School, Boston, MA, USA.

Regan C ManayanDepartment of Otolaryngology - Head and Neck Surgery, Harvard Medical School, Boston, MA, USA.

Michiya NishinoDivision of Otolaryngology, Head and Neck Surgery, Beth Israel Deaconess Medical Center, 110 Francis St., Suite 6E, Boston, MA, 02215, USA.

Ernest D GomezDepartment of Otolaryngology - Head and Neck Surgery, Harvard Medical School, Boston, MA, USA. egomez@bidmc.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the case of a 51-year-old man with Von Hippel-Lindau disease and a history of renal transplantation who developed a persistent, painful tongue lesion with episodes of significant swelling. Given his history of prolonged immunosuppression and elevated cancer risk, oral squamous cell carcinoma was a major concern. However, histopathological evaluation confirmed recrudescent herpes simplex virus (HSV) infection rather than malignancy. The lesion fully resolved with antiviral therapy. This case is notable for its presentation mimicking malignancy in a high-risk patient and highlights the importance of considering infectious etiologies in immunosuppressed individuals. It underscores the need for thorough histopathologic evaluation to prevent misdiagnosis and ensure appropriate treatment, especially in patients at increased risk for both infection and cancer.

Indexed as

Tongue Neoplasmsvon Hippel-Lindau DiseaseCarcinoma, Squamous CellDiagnosis, DifferentialHerpes SimplexHumansImmunocompromised HostMaleMiddle AgedSimplexvirusSquamous Cell Carcinoma of Head and NeckHerpes simplex virus (HSV)ImmunosuppressionOral squamous cell carcinomaTongue lesionTransplant-associated malignancyUlcerated mass

Identifiers

PMID39775472

DOI10.1007/s12105-024-01721-7

PMCPMC11706810

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.