Evidence map›Paper›PMID 39775243›Full record

SynthesisInflammopharmacology2025

Impacts of supplementation with milk proteins on inflammation: a systematic review and meta-analysis.

Shooka Mohammadi, Damoon Ashtary-Larky, Milad Mehrbod, Narges Kouhi Sough, Hossein Salehi Omran, Sina Dolatshahi, Niusha Amirani, Omid Asbaghi

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shooka MohammadiNutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. shooka.mohammadi@gmail.com.ORCID http://orcid.org/0000-0001-9157-1922
Damoon Ashtary-LarkyNutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Milad MehrbodSchool of Medicine, University of Louisville, Louisville, KY, USA.
Narges Kouhi SoughFaculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.
Hossein Salehi OmranFaculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sina DolatshahiFaculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Niusha AmiraniFaculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Omid AsbaghiCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. omid.asbaghi@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImpacts of milk proteins (MPs) on inflammation are uncertain. The current systematic review and dose-response meta-analysis of randomized controlled trials (RCTs) evaluated the effects of whey protein (WP), casein protein (CP), or MP supplementation on serum levels of cytokines and adipokines in adults.

methodsA comprehensive search of various online databases was conducted to find appropriate clinical trials published until September 2024. A random-effect statistical model was implemented.

resultsThe meta-analysis included 53 RCTs. It was indicated that MP supplements had no substantial effects on serum values of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), adiponectin, and leptin. However, there were statistically significant decreases in serum levels of interleukin-6 (IL-6) following supplementation with MP (weighted mean difference (WMD): - 0.25 pg/mL, 95% CI - 0.48, - 0.03; P = 0.026) in the intervention group compared with the control group.

conclusionThis study revealed that MP supplementation may not have any considerable impacts on the levels of cytokines and adipokines.

Indexed as

Dietary SupplementsInflammationMilk ProteinsAdipokinesCaseinsC-Reactive ProteinCytokinesHumansRandomized Controlled Trials as TopicWhey ProteinsAdipokinesCaseinsC-Reactive ProteinCytokinesMilk ProteinsWhey ProteinsAdiponectinCaseinCytokinesLeptinMilk proteinWhey

Identifiers

PMID39775243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.