Evidence map›Paper›PMID 39774994›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025

Survival and toxicity outcomes of hypofractionated conformal radiotherapy compared to conventionally fractionated radiotherapy in the treatment of diffuse intrinsic pontine gliomas.

Abhilash Dagar, Adrija Ghosh, Aashita, Akash Kumar, Yousra Izzuddeen K N, Karun Kamboj, Aman Sharma, Jaswin Raj, Dayanand Sharma, Supriya Mallick

Abstract readComparative Study
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In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abhilash DagarDepartment of Radiation Oncology, National Cancer Institute, All India Institute of Medical Sciences, New Delhi, India.
Adrija GhoshDepartment of Radiation Oncology, National Cancer Institute, All India Institute of Medical Sciences, New Delhi, India.
AashitaDepartment of Radiation Oncology, National Cancer Institute, All India Institute of Medical Sciences, New Delhi, India.
Akash KumarDepartment of Medical Oncology, National Cancer Institute, All India Institute of Medical Sciences, New Delhi, India.
Yousra Izzuddeen K NDepartment of Radiation Oncology, National Cancer Institute, All India Institute of Medical Sciences, New Delhi, India.
Karun KambojDepartment of Radiation Oncology, National Cancer Institute, All India Institute of Medical Sciences, New Delhi, India.
Aman SharmaDepartment of Radiation Oncology, National Cancer Institute, All India Institute of Medical Sciences, New Delhi, India.
Jaswin RajDepartment of Radiation Oncology, National Cancer Institute, All India Institute of Medical Sciences, New Delhi, India.
Dayanand SharmaDepartment of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
Supriya MallickDepartment of Radiation Oncology, National Cancer Institute, All India Institute of Medical Sciences, New Delhi, India. drsupriyamallick@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDiffuse intrinsic pontine gliomas are associated with dismal survival outcomes. Conventional fractionation radiation to a dose of 60 Gy is the standard of treatment. This retrospective review aims to compare survival and toxicity outcomes of patients treated with conventional fractionation (CF) and hypofractionation (HF) radiotherapy. MATERIALS AND

methodsTreatment-naïve diffuse intrinsic pontine glioma patients undergoing radical radiation were analyzed. CF was delivered to a dose of 50-60 Gy in 25-30 fractions, while HF was delivered as 38-40 Gy in 12-15 fractions. All patients were planned via the volumetric modulated arc therapy (VMAT) technique.

resultsA total of 64 patients were eligible for analysis. The median age of presentation was 10 years. Motor deficit was the most common presenting complaint in 51.6% of the patients, with a median symptom duration of 2 months. The pons was the most frequent site of disease epicenter in 71.8% of the patients. After a median follow-up of 9.45 months (range 0.23-72.63 months), 23 patients died, and 28 patients experienced disease progression. The unadjusted hazard ratio (HR) for death in patients treated with HF as compared to CF was 1.330 (95% CI 0.522-3.386) (p-value 0.550, by Cox regression analysis). The median OS for the entire cohort was 13.9 months, while it was 9.7 months (95% CI 5.65-13.74) and 15.1 months (95% CI 9.02-21.18) (p-value = 0.547) with CF and HF, respectively. On multivariate analysis, disease epicenter in the pons was the only significant factor associated with PFS. Hypofractionation was associated with a significantly higher aspiration rate and Ryle's tube requirement (p-value 0.027).

conclusionHypofractionated radiation can be considered for diffuse intrinsic pontine glioma with optimum supportive care.

Indexed as

Brain Stem NeoplasmsDiffuse Intrinsic Pontine GliomaDose Fractionation, RadiationRadiation Dose HypofractionationRadiotherapy, ConformalAdolescentChildChild, PreschoolFemaleHumansMaleRetrospective StudiesTreatment OutcomeYoung AdultComplianceConformalConventionaldiffuse intrinsic pontine gliomaHypofractionatedRadiotherapy

Identifiers

PMID39774994

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.