ArticleScientific reports2025
Ten-year outcomes after DMEK, DSAEK, and PK: insights on graft survival, endothelial cell density loss, rejection and visual acuity.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Predictors of long-term graft survival after descemet membrane endothelial keratoplasty.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Ten-year outcomes of endothelial keratoplasty versus penetrating keratoplasty in Hong Kong: a retrospective cohort study.BMC ophthalmology · 2026Article
- Corneal Remodeling After DMEK in Fuchs Endothelial Dystrophy Patients: Quantitative and Qualitative Changes.Life (Basel, Switzerland) · 2026Article
- Epithelial Thickness Changes After Descemet Membrane Endothelial Keratoplasty (DMEK): An Observational Study.Journal of clinical medicine · 2026Article
- Development and Clinical Validation of the DMEK Risk and Outcome Prediction (DROP) Score: A Dynamic Temporal Machine Learning Framework.Journal of clinical medicine · 2026Article
- Review
- Long-Term Clinical Outcomes of nDSAEK and Machine Learning-Based Prediction of Graft Survival in Corneal Endothelial Decompensation.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- A novel single-cell level evaluation method for corneal endothelial cell function.NPJ digital medicine · 2025Article
- Long-term outcomes of DSAEK at a tertiary eye center in Saudi Arabia: a 15-year retrospective review.International ophthalmology · 2025Article
- Long-Term Outcome of Endothelial Keratoplasty Among Glaucoma Patients and the Risk of Prostaglandin Analogue (Latanoprost) Use on Graft Rejection.Journal of clinical medicine · 2025Article
- Bioengineering Strategies for Corneal Endothelial Cell Injection Therapy: Advances, Challenges, and Clinical Translation.Bioengineering (Basel, Switzerland) · 2025Review
- Emerging Innovations in the Treatment of Fuchs Endothelial Corneal Dystrophy: A Narrative Review.Medical sciences (Basel, Switzerland) · 2025Review
- Clinical and epidemiological factors affecting donor corneal endothelial cell density.BMJ open ophthalmology · 2025Article
- Non-Descemet Stripping Automated Endothelial Keratoplasty (nDSAEK) for Late Endothelial Failure After Mushroom Keratoplasty: A Retrospective Analysis of Visual and Anatomical Outcomes.Journal of clinical medicine · 2025Article
- A Review of Outcomes of Descemet Membrane Endothelial Keratoplasty and Descemet Stripping Automated Endothelial Keratoplasty Interventions in Patients with Pre-Existing Glaucoma.Journal of clinical medicine · 2025Review
- Review of the Literature: Surgery Indications for Fuchs' Endothelial Corneal Dystrophy.Journal of clinical medicine · 2025Review
- Deep learning-assisted widefield endothelial imaging in Descemet membrane endothelial keratoplasty.Frontiers in medicine · 2025Article
- Safety Profile of Intraoperative Corneal Debridement in Descemet Membrane Endothelial Keratoplasty (DMEK)-A Retrospective Comparative Study.Journal of ophthalmology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fuchs Endothelial Corneal Dystrophy (FECD) is the most frequent indication for corneal transplantation, with Descemet membrane endothelial keratoplasty (DMEK), Descemet stripping automated endothelial keratoplasty (DSAEK), and penetrating keratoplasty (PK) being viable options. This retrospective study compared 10-year outcomes of these techniques in a large cohort of 2956 first-time keratoplasty eyes treated for FECD at a high-volume corneal transplant center in Germany. While DMEK and DSAEK provided faster visual recovery (median time to BSCVA ≥ 6/12 Snellen: DMEK 7.8 months, DSAEK 12.4 months, PK 37.9 months; cumulative probability of BSCVA ≥ 6/12 Snellen within 5 years: DMEK 93%, DSAEK 83%, PK 63%), PK surprisingly exhibited superior long-term graft survival (92% vs. 75% for DMEK and 73% for DSAEK at 10 years). Endothelial cell density (ECD) decreased significantly faster after DMEK and DSAEK, potentially contributing to their lower graft survival (10-year ECD > 1000 cells/mm
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