Observational studyIntensive care medicine2025
Left ventricular diastolic dysfunction is prevalent but not associated with mortality in patients with septic shock.
Observational study in Intensive care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02918214 (Prognostic Assessment of Diastolic and Systolic Left Ventricular Function in Septic Shock), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prognostic Assessment of Diastolic and Systolic Left Ventricular Function in Septic Shock
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- ESICM guidelines on circulatory shock and hemodynamic monitoring 2025.Intensive care medicine · 2025Guideline
- A structured 5-question approach for echocardiographic evaluation of undifferentiated shock.Echo research and practice · 2026Review
- Echoes of concern: scrutinizing diastolic dysfunction with established guidelines.Journal of anesthesia · 2026Article
- Revisiting septic cardiomyopathy: the missing role of systolic function in interpreting diastolic dysfunction and outcomes. Author's reply.Intensive care medicine · 2026Article
- Revisiting septic cardiomyopathy: the missing role of systolic function in interpreting diastolic dysfunction and outcomes.Intensive care medicine · 2026Article
- Ten Influential Point-of-Care Ultrasound Papers: 2025 in Review.Journal of intensive care medicine · 2026Review
- Impact of heart rate on Doppler echocardiography predictors of rhythm control in patients with septic shock.Scientific reports · 2026Article
- Echocardiographic phenotypes in sepsis: identifying subgroups using latent profile analysis.Journal of intensive care · 2026Article
- Update on sepsis and septic shock: from bundles to precision medicine.Intensive care medicine · 2026Article
- Treatment of supraventricular arrhythmias in critical care patients with sepsis.Frontiers in cardiovascular medicine · 2026Review
- Echocardiographic assessment of left ventricular filling pressure compared to pulmonary artery catheter in mechanically ventilated patients: Systematic review and meta-analysis.Annals of intensive care · 2026Review
- Impact of left ventricular ejection fraction on unplanned readmission after aortic regurgitation surgery: a single-center retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- Echocardiography guided management of atrial fibrillation.Intensive care medicine · 2025Review
- Sepsis-induced myocardial dysfunction diagnosed with strain versus non-strain echocardiography parameters: incidence, evolution and association with prognosis.Annals of intensive care · 2025Article
- Impact of preoperative diastolic dysfunction on short-term outcomes following robotic-assisted minimally invasive esophagectomy (RAMIE).Journal of robotic surgery · 2025Article
- Left atrial reservoir strain: an essential tool for evaluating left ventricular diastolic dysfunction in 2025-response. Authors' reply.Intensive care medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePrognostic impact of left ventricular diastolic dysfunction (LVDD) in septic shock patients has not been determined using current diagnostic guidelines. We assessed the relation between LVDD during the first 3 days following intensive care unit (ICU) admission for septic shock and Day-28 mortality.
methodsThis prospective, multicenter, observational study enrolled 402 patients (age: 63 ± 13 year; 59% male; SAPS II: 59 ± 20; SOFA: 9.4 ± 3.6; mechanical ventilation: 74%) with septic shock (Sepsis-3 definition). Patients were echocardiographically assessed within 12 h after admission (Day 1), on Day 2, Day 3, at ICU and at hospital discharge (or Day 28 whichever occurred first), using 2016 American-European guidelines.
resultsLVDD was present at least once between Day 1 and 3 in 304 patients (76%), and in 56% and 44% of patients at ICU discharge and on Day 28 (or hospital discharge), respectively (43% of patients with follow-up). Seventy-eight of 172 patients (45%) exhibited similar LV diastolic properties throughout the study period while 58 patients (34%) improved their LVDD at follow-up (lower grade: n = 9, regression: n = 49). Day-28 mortality was not statistically different between patients with and without LVDD (80/304 [26%] vs. 25/88 [28%]; OR: 0.900 [0.530-1.527]; p = 0.696). Similar results were obtained when adjusting the multivariate model on SAPSII or SOFA score on admission, together with fluid balance during the first three days of ICU stay (OR: 0.838 [0.471-1.491]: p = 0.547 and OR: 0.887 [0.513-1.534]: p = 0.668, respectively).
conclusionLVDD was highly prevalent in patients with septic shock but not associated with mortality. It appeared improving in one-third of survivors.
trial registrationPRODIASYS study registered on ClinicalTrials (September 27, 2016, number NCT02918214).
Indexed as
Identifiers
39774865What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.