Evidence map›Paper›PMID 39774817›Full record

ArticleCommunications medicine2025

Genetically engineered pig heart transplantation in non-human primates.

Avneesh K Singh, Corbin E Goerlich, Tianshu Zhang, Billeta Lewis, Alena Hershfeld, Gheorghe Braileanu, Kasinath Kurvi, Kathryn Rice, Faith Sentz, Sarah Mudd and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Avneesh K Singh *Department of Surgery, The University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-8701-2260
Corbin E Goerlich *Department of Surgery, The University of Maryland School of Medicine, Baltimore, MD, USA.
Tianshu ZhangDepartment of Surgery, The University of Maryland School of Medicine, Baltimore, MD, USA.
Billeta LewisDepartment of Surgery, The University of Maryland School of Medicine, Baltimore, MD, USA.
Alena HershfeldDepartment of Surgery, The University of Maryland School of Medicine, Baltimore, MD, USA.
Gheorghe BraileanuDepartment of Surgery, The University of Maryland School of Medicine, Baltimore, MD, USA.
Kasinath KurviRevivicor Inc, Blacksburg, VA, USA.
Kathryn RiceDepartment of Pathology, The University of Maryland School of Medicine, Baltimore, MD, USA.
Faith SentzDepartment of Surgery, The University of Maryland School of Medicine, Baltimore, MD, USA.
Sarah MuddDepartment of Surgery, The University of Maryland School of Medicine, Baltimore, MD, USA.
Patrick OdonkorDepartment of Anesthesiology, The University of Maryland School of Medicine, Baltimore, MD, USA.
Erik StraussDepartment of Anesthesiology, The University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6424-9441
Brittney WilliamsDepartment of Anesthesiology, The University of Maryland School of Medicine, Baltimore, MD, USA.
Allen BurkeDepartment of Pathology, The University of Maryland School of Medicine, Baltimore, MD, USA.
Anuj GuptaDepartment of Medicine, Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Cinthia B DrachenbergDepartment of Pathology, The University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3104-5661
David AyaresRevivicor Inc, Blacksburg, VA, USA.
Bartley P GriffithDepartment of Surgery, The University of Maryland School of Medicine, Baltimore, MD, USA.
Muhammad M MohiuddinDepartment of Surgery, The University of Maryland School of Medicine, Baltimore, MD, USA. MMohiuddin@som.umaryland.edu.ORCID http://orcid.org/0000-0003-4654-783X

Funding

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 5U19090959-10
6 · The paper itself

Abstract

backgroundImprovement in gene modifications of donor pigs has led to the prevention of early cardiac xenograft rejection and significantly prolonged cardiac xenograft survival in both heterotopic and orthotopic preclinical non-human primate (NHP) models. This progress formed the basis for FDA approval for compassionate use transplants in two patients.

methodsBased on our earlier report of 9-month survival of seven gene-edited (7-GE) hearts transplanted (life-supporting orthotopic) in baboons, we transplanted 10 gene-edited pig hearts into baboons (n = 4) using non-ischemic continuous perfusion preservation (NICP) and immunosuppression regimen based on co-stimulation blockade by anti-CD40 monoclonal antibody. This pivotal study expands on the 7-GE backbone, with 3 additional gene edits, using 10-GE pigs as donors to baboon recipients.

results10 GE cardiac xenografts provide life-supporting function up to 225 days (mean 128 ± 36 days) in a non-human primate model. Undetectable or latent porcine cytomegalovirus (PCMV) does not influence cardiac xenograft survival in this study but still needs more exploration with a larger cohort. Xenograft histology demonstrates adipose (Fat) deposition (n = 1), chronic vasculopathy (n = 1), micro and macro thrombosis, and acute cellular rejection (n = 1).

conclusionsThese data demonstrate that 10 GE cardiac xenografts have variable cardiac xenograft survival in NHP due to perhaps presence of 4th antigen and require further study. However, these 10GE organs may be suitable for clinical cardiac xenotransplantation and have already been utilized in two human cases.

Identifiers

PMID39774817
PMCPMC11707197

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.