ArticleScientific reports2025
Medication non-adherence and its predictors among patients with bipolar disorder in Northwest Ethiopia.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Determinants of non-adherence to diabetes treatment among patients at Hawassa University Comprehensive Referral Hospital, Ethiopia.African health sciences · 2026Article
- Predicting Medication Adherence in Sickle Cell Disease and Thalassemia in Oman: The Role of Beliefs and Fatigue.Patient preference and adherence · 2026Article
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6 authors.
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Abstract
While pharmacotherapy is the primary approach for treating patients with bipolar disorder, non-adherence is the most common barrier preventing these patients from achieving optimal medication effectiveness. This study aimed to assess medication non-adherence and its predictors among patients with bipolar disorder in Northwest Ethiopia. A hospital-based cross-sectional study was conducted among 404 patients with bipolar disorder in Northwest Ethiopia from January to March 2024. Study participants were enrolled using systematic random sampling. Medication non-adherence was measured using the Medication Adherence Rating Scale (MARS). Data were entered and analyzed using Epi-data version 4.6.0 and SPSS version 26, respectively. A multivariable logistic regression model was fitted to identify predictors of medication non-adherence. Variables with a P-value < 0.05 at a 95% confidence interval were considered statistically significant. The prevalence of medication non-adherence was 39.9%. Number of admissions (AOR = 2.83, 95% CI 1.21, 6.59), suicidal attempts (AOR = 2.75, 95% CI 1.14, 6.63), current substance use (AOR = 2.09, 95% CI 1.13, 3.85) and social support (AOR = 3.57, 95% CI 1.08, 11.81) were statistically significant predictors of medication non-adherence. In this study, more than one-third of the respondents were found to be non-adherent. Participants with frequent admissions, suicidal attempts, current substance use and poor social support require prompt screening and critical follow-up to improve medication adherence.
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