Evidence map›Paper›PMID 39774731›Full record

ArticleSao Paulo medical journal = Revista paulista de medicina2024

Diagnosis and treatment of latent tuberculosis infection among household contacts in inland Bahia, Brazil: a cross-sectional follow-up study.

Guilherme Lages Matias, Marcio Vinicius Ferreira Sales, Gabriela Santos Andrade, Brenda Dos Santos Teixeira, Maria Eduarda da Macena Tenorio, Maria Augusta Vasconcelos Palácio, Maria Luisa de Carvalho Correia, Iukary Takenami

Abstract read
In one paragraph

Article in Sao Paulo medical journal = Revista paulista de medicina, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guilherme Lages MatiasUndergraduate Student, College of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF), Paulo Afonso (BA), Brazil.ORCID 0000-0002-0016-246X
Marcio Vinicius Ferreira SalesUndergraduate Student, College of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF), Paulo Afonso (BA), Brazil.ORCID 0009-0003-2730-3319
Gabriela Santos AndradeUndergraduate Student, College of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF), Paulo Afonso (BA), Brazil.ORCID 0000-0003-4958-9904
Brenda Dos Santos TeixeiraUndergraduate Student, College of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF), Paulo Afonso (BA), Brazil.ORCID 0000-0001-6062-9669
Maria Eduarda da Macena TenorioUndergraduate Student, College of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF), Paulo Afonso (BA), Brazil.ORCID 0000-0002-2548-5927
Maria Augusta Vasconcelos PalácioAdjunt Professor, College of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF), Paulo Afonso (BA), Brazil.ORCID 0000-0002-2780-125X
Maria Luisa de Carvalho CorreiaDermatology and Sanitary Pneumology Service (SEDERPAS), Municipal Health Department, Paulo Afonso (BA), Brazil.ORCID 0000-0003-3373-0264
Iukary TakenamiAdjunt Professor, College of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF), Paulo Afonso (BA), Brazil.ORCID 0000-0001-5660-7766

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe diagnosis and treatment of latent tuberculosis infection (LTBI) are crucial for tuberculosis (TB) control. Household contacts (HHC) of patients with pulmonary TB are at a high risk of LTBI due to their close proximity to source cases.

objectiveTo describe the diagnosis and treatment of LTBI among HHC. DESIGN AND

settingThis cross-sectional follow-up study was conducted in the municipality of Paulo Afonso, northeastern Brazil, between 2013 and 2022.

methodsWe retrieved secondary data from the medical records of HHC who were followed up at a specialized referral center for TB. LTBI prevalence estimates were calculated and are presented with 95% confidence intervals (CIs).

resultsIn total, 622 HHC were screened for LTBI, with 620 evaluated using the tuberculin skin test (TST). Of these, 40 (6.5%) did not return for TST reading. The overall prevalence of LTBI was 53.1% (95% CI: 49-57.1%), with a high prevalence among females and individuals aged 25-34 years. The overall LTBI treatment initiation rate was 26.1% (95%CI: 21.5-31.3%), and 64.2% (95%CI: 53.3-73.8%) of HHC who initiated treatment completed their course.

conclusionThis study revealed a high prevalence of LTBI among HHC, particularly among women and individuals aged 25-34 years, underscoring the ongoing TB transmission within the community. Only 26.1% of the diagnosed HHC initiated treatment, with approximately 64% completing their course. This highlights the challenges in managing LTBI and emphasizes the need for targeted screening and interventions for high-risk groups.

Indexed as

Contact TracingFamily CharacteristicsLatent TuberculosisTuberculin TestAdolescentAdultAgedAntitubercular AgentsBrazilChildChild, PreschoolCross-Sectional StudiesFemaleFollow-Up StudiesHumansInfantAntitubercular Agents

Identifiers

PMID39774731
PMCPMC11655036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.