Evidence map›Paper›PMID 39774185›Full record

ArticleScientific reports2025

Restoration effect of chemically modified microRNA-143-3p on acute myocardial infarction in animal models.

Shingo Minatoguchi, Nobuhiko Sugito, Kazuki Heishima, Yuko Ito, Remi Nakashima, Hiroyuki Okura, Yukihiro Akao, Shinya Minatoguchi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shingo Minatoguchi *Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan.
Nobuhiko Sugito *United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.
Kazuki HeishimaUnited Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.
Yuko ItoDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Remi NakashimaUnited Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.
Hiroyuki OkuraDepartment of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan.
Yukihiro AkaoUnited Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan. akao.yukihiro.v6@a.gifu-u.ac.jp.
Shinya MinatoguchiDepartment of Circulatory and Respiratory Advanced Medicine, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu, 501-1194, Japan. minatoguchi.shinya@a.gifu-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated whether miR143#12, a synthesized chemically modified miR-143-3p derivative, exerts therapeutic effects on acute myocardial infarction (AMI). Sprague-Dawley rats and Japanese white rabbits underwent 30 min of coronary occlusion followed by 2 weeks of reperfusion. The rat AMI model was intravenously administered with control miRNA (9 μg/kg), 3 μg/kg or 9 μg/kg of miR143#12 1 h after reperfusion, while the rabbit AMI model was intravenously administered with control miRNA (9 μg/kg) or 9 μg/kg of miR143#12. In the rat and rabbit AMI models, 9 μg/kg of miR143#12 significantly reduced infarct sizes and significantly improved cardiac function including LVEF and LVFS at 2 weeks. The tissue miR143 levels in infarct areas significantly decreased after AMI in both models. Electron microscopic study and immunohistochemistry suggested that miR143#12 suppressed autophagic cell death caused by AMI and induced neoangiogenesis in the infarct border. In cultured rat H9c2 cells, miR143#12 significantly inhibited H

Indexed as

Disease Models, AnimalMicroRNAsMyocardial InfarctionRats, Sprague-DawleyAnimalsAutophagyCell LineHydrogen PeroxideMaleRabbitsRatsReactive Oxygen SpeciesHydrogen PeroxideMicroRNAsMIRN143 microRNA, ratReactive Oxygen SpeciesAngiogenesisATG7Autophagic cell deathCardiac functionChemically modified miR143COX-1COX-2Infarct sizeMyocardial infarction

Identifiers

PMID39774185
PMCPMC11707079

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.