ArticleScientific reports2025
The pathomechanism of bone marrow edema in the femoral head necrosis with pericollapse stage.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The Role of SIRT1 in Mediating Bone Marrow Edema and Its Interface With Bone Remodeling.Immunity, inflammation and disease · 2026Review
- Vascularized bone organoids: current advances and a biomimetic platform for osteonecrosis of the femoral head.Bone research · 2026Review
- Total hip arthroplasty with tantalum rod extraction via direct anterior approach based on preoperative DCE-MRI and AI: a case report.Annals of medicine and surgery (2012) · 2025Article
- Microstructural and transcriptomic characterization of trabecular bone in idiopathic osteonecrosis of the femoral head.Scientific reports · 2025Article
- PTGS2 Is Involved in Osteonecrosis of the Femoral Head and Bone Marrow Edema.International journal of genomics · 2025Article
- Senescence-driven osteonecrosis of the femoral head in the elderly-a distinct pathophysiological entity.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Bone marrow edema (BME), a notable manifestation during the progression of osteonecrosis of the femoral head (ONFH), exhibits significant associations with femoral head collapse, pain, and prognosis, howeverits' pathogenesis remains underexplored. In this study, specimens from patients undergoing total hip arthroplasty (THA) were analyzed. The results revealed significantly higher Visual Analog Scale (VAS) scores and CT low-density area ratio in the BME group compared to the control group. Furthermore, Sirius Red staining exhibited fibrotic tissue in both necrotic and sclerotic areas, with more pronounced effects in the BME group. Meanwhile, data-independent Acquisition (DIA) proteomics technology was utilized to identify differentially expressed proteins (DEPs) within bone tissue. 141, 299 and 852 DEPs were identified in femoral neck, necrotic and sclerotic regions, respectively. Immune responses, inflammatory reactions and oxidative stress were markedly altered in ONFH cases with BME. In bone tissue, the levels of malondialdehyde (MDA) and proteins associated with osteoclast activity were found to be elevated in the BME group. In conclusion, BME in ONFH at pericollapse stage is associated with inflammation, fibrosis, heightened oxidative stress and increased osteoclast activity. These factors collectively elevated the risk of collapse or re-collapse. Targeted interventions aimed at neutralizing these risk factors show potential in slowing down the progression of the disease.
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Registered trials
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