Evidence map›Paper›PMID 39773817›Full record

ArticleDevelopment and psychopathology2025

Proinflammatory gene expression is associated with prospective risk for adolescent suicidal thoughts and behaviors over twelve months.

Matthew G Clayton, Steve W Cole, Matteo Giletta, Paul D Hastings, Matthew K Nock, Karen D Rudolph, George M Slavich, Mitchell J Prinstein

Abstract read
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In one paragraph

Article in Development and psychopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Alterations of pro- and anti-inflammatory cytokines balance and superoxide dismutase in the dorsolateral prefrontal cortex of suicide decedents.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew G ClaytonDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0002-6748-5714
Steve W ColeDivision of Hematology-Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Matteo GilettaDepartment of Psychology, Ghent University, Ghent, Belgium.
Paul D HastingsCenter for Mind and Brain and Department of Psychology, University of California, Davis, CA, USA.ORCID https://orcid.org/0000-0003-2978-7364
Matthew K NockDepartment of Psychology, Harvard University, Boston, MA, USA.
Karen D RudolphDepartment of Psychology, University of Illinois at Urbana-Champaign, Urbana-Champaign, IL, USA.ORCID https://orcid.org/0000-0002-6190-3356
George M SlavichDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0001-5710-3818
Mitchell J PrinsteinDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0002-7587-8665

Funding

Multilevel Biomarkers for Suicidal Behavior: From Interpersonal Stress to Gene Expression in a Longitudinal Study of Adolescent GirlsR01MH107479 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NOCK, MATTHEW K, PRINSTEIN, MITCHELL J · 2015 to 2019
$4.6M
NIMH NIH HHS R01 MH107479
6 · The paper itself

Abstract

objectiveRecent theories have implicated inflammatory biology in the development of psychopathology and maladaptive behaviors in adolescence, including suicidal thoughts and behaviors (STB). Examining specific biological markers related to inflammation is thus warranted to better understand risk for STB in adolescents, for whom suicide is a leading cause of death.

methodParticipants were 211 adolescent females (ages 9-14 years;

resultsControlling for past levels of STB, greater proinflammatory gene expression was associated with prospective risk for STB in these youth. Similar effects were observed for CD14 mRNA level, a marker of monocyte abundance within the blood sample. Sensitivity analyses controlling for other relevant covariates, including history of trauma, depressive symptoms, and STB prior to data collection, yielded similar patterns of results.

conclusionsUpregulated inflammatory signaling in the immune system is prospectively associated with STB among at-risk adolescent females, even after controlling for history of trauma, depressive symptoms, and STB prior to data collection. Additional research is needed to identify the sources of inflammatory up-regulation in adolescents (e.g., stress psychobiology, physiological development, microbial exposures) and strategies for mitigating such effects to reduce STB.

Indexed as

Adolescent BehaviorGene ExpressionInflammationSuicidal IdeationAdolescentChildDepressionFemaleHumansProspective StudiesRisk FactorsSuicide, Attemptedadolescencebiomarkerschildhood traumainflammationsuicide

Identifiers

PMID39773817
PMCPMC13023108

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.