ArticleBMC medicine2025
Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts.
Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness and Experiences of Self-Management Interventions in Adults With Multiple Long-Term Conditions: A Mixed Methods Systematic Review.Journal of evaluation in clinical practice · 2026Pooled it
- Personalised exercise-rehabilitation for people with multiple long-term conditions (PERFORM): a randomised feasibility study.BMJ open · 2025Trial
- Patterns of multimorbidity and in-hospital kidney function decline in older adults: a latent class analysis of three acute-care cohorts.Internal and emergency medicine · 2026Article
- Validation of an Algorithmic Pipeline for Wrist-Worn Devices to Estimate Walking Speed in People with Multiple Long-Term Conditions.Sensors (Basel, Switzerland) · 2026Article
- Endostatin, chronic kidney disease (CKD) and anemia among older people: a secondary analysis of the screening for CKD among older people across Europe (SCOPE) study.Journal of translational medicine · 2026Article
- Article
- Serum uric acid, gout, cardiometabolic diseases, and multimorbidity: a prospective cohort study using multi-state model.npj aging · 2026Article
- Training needs and curricular priorities for managing multimorbidity in Spanish primary care: findings from a national exploratory online survey.BMC primary care · 2026Article
- Quality of life among women of reproductive age during the accumulation of multiple chronic conditions.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Combining polygenic risk scores to understand genetic liability to physical-mental health multimorbidity in UK Biobank.Human molecular genetics · 2026Article
- Impact of multimorbidity on change in quality of life in a multi-ethnic Asian population: a longitudinal study.Health and quality of life outcomes · 2026Article
- Prevalence and Outcomes of Frailty in Older Men-the Manitoba Follow-Up Study.Canadian geriatrics journal : CGJ · 2026Article
- Healthy Lifestyle, multimorbidity network, and all-cause mortality among older Chinese: a longitudinal analysis in Chinese longitudinal healthy longevity survey.BMC public health · 2026Article
- Ethnic differences in the patterns, incidence and prevalence of multiple long-term conditions: a systematic review protocol.Wellcome open research · 2026Article
- Machine learning identifies clusters of multimorbidity among decedents with inflammatory bowel disease.Communications medicine · 2025Article
- Clusters of Comorbidities in Multiple Sclerosis and Their Influence on Healthcare Resource Usage.European journal of neurology · 2025Observational
- Real-World Wrist-Derived Digital Mobility Outcomes in People with Multiple Long-Term Conditions: A Comparison of Algorithms.Bioengineering (Basel, Switzerland) · 2025Article
- Development and psychometric testing of symptom severity scale in older patients with cardiometabolic multimorbidity.BMC geriatrics · 2025Article
- Prevalence and factors associated with cardiometabolic multimorbidity: a cross-sectional study in older adults of the first Brazilian hypertension registry.BMC cardiovascular disorders · 2025Article
- Joint Associations of Frailty and Cardiometabolic Diseases With Risk of All-Cause and Cardiac Mortality.JACC. Asia · 2025Article
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Authors and funding
26 authors.
Funding
Abstract
backgroundIdentifying clusters of multiple long-term conditions (MLTCs), also known as multimorbidity, and their associated burden may facilitate the development of effective and cost-effective targeted healthcare strategies. This study aimed to identify clusters of MLTCs and their associations with long-term health-related quality of life (HRQoL) in two UK population-based cohorts.
methodsAge-stratified clusters of MLTCs were identified at baseline in UK Biobank (n = 502,363, 54.6% female) and UKHLS (n = 49,186, 54.8% female) using latent class analysis (LCA). LCA was applied to people who self-reported ≥ 2 LTCs (from n = 43 LTCs [UK Biobank], n = 13 LTCs [UKHLS]) at baseline, across four age-strata: 18-36, 37-54, 55-73, and 74 + years. Associations between MLTC clusters and HRQoL were investigated using tobit regression and compared to associations between MLTC counts and HRQoL. For HRQoL, we extracted EQ-5D index data from UK Biobank. In UKHLS, SF-12 data were extracted and mapped to EQ-5D index scores using a standard preference-based algorithm. HRQoL data were collected at median 5 (UKHLS) and 10 (UK Biobank) years follow-up. Analyses were adjusted for available sociodemographic and lifestyle covariates.
resultsLCA identified 9 MLTC clusters in UK Biobank and 15 MLTC clusters in UKHLS. Clusters centred around pulmonary and cardiometabolic LTCs were common across all age groups. Hypertension was prominent across clusters in all ages, while depression featured in younger groups and painful conditions/arthritis were common in clusters from middle-age onwards. MLTC clusters showed different associations with HRQoL. In UK Biobank, clusters with high prevalence of painful conditions were consistently associated with the largest deficits in HRQoL. In UKHLS, clusters of cardiometabolic disease had the lowest HRQoL. Notably, negative associations between MLTC clusters containing painful conditions and HRQoL remained significant even after adjusting for number of LTCs.
conclusionsWhile higher LTC counts remain important, we have shown that MLTC cluster types also have an impact on HRQoL. Health service delivery planning and future intervention design and risk assessment of people with MLTCs should consider both LTC counts and MLTC clusters to better meet the needs of specific populations.
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