ArticleCaries research2025
Microbiome in Early Childhood Caries: Caries Severity-Dependent Insights.
Article in Caries research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChildren with early childhood caries (ECC) show different caries severities and susceptibility in different tooth types and location in the oral cavity. The study aimed to investigate differences in the oral microbiome in ECC subjects stratified according to the severity of caries and between more and less caries-prone teeth within the same subjects.
methodsSupragingival plaque from the upper and lower anterior regions in the oral cavity of subjects were collected in 3 groups of increasing caries severity: G1 - molar (M) caries only; G2 - molar and upper anterior (UA) caries; and G3 - M + UA + lower anterior (LA) caries followed by microbiome analysis.
resultsAlpha-diversity analyses showed inter- but no intra-individual statistically significant differences between the UA and LA (p < 0.001, LA > UA) and a significant difference between the microbiome of the three caries groups (p < 0.001). There were significant beta-diversity differences between G1 and G2 (p < 0.05) and in the composition and diversity among the three groups (p < 0.001). Actinomyces, Saccharibacteria_genera_inserta_sedis, and Eikenella had increased differential abundance in G1 versus G3 and Fusobacterium was less abundant in G2 compared to the other groups.
conclusionsThere were clear distinct differences in tooth-site-specific and caries-severity microbiome diversity patterns and bacterial abundance profiles in S-ECC children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.