Evidence map›Paper›PMID 39773552›Full record

ArticleThe American journal of tropical medicine and hygiene2025

Recurrent Plasmodium falciparum Malaria in U.S. Travelers Treated with Artemether-Lumefantrine.

Hendrik Sy, Sharan Yadav, Peter Yangga, Alexander Shaffer, Amie John, Wesley Rogers, Lars Westblade, Rebecca Marrero Rolón, Susan Madison-Antenucci, Phyu M Thwe and 5 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hendrik SyDivision of Infectious Diseases, Montefiore Medical Center/Albert Einstein College of Medicine, New York, New York.
Sharan YadavDivision of Infectious Diseases, Weill Cornell Medicine, New York, New York.
Peter YanggaDivision of Infectious Diseases, Montefiore Medical Center/Albert Einstein College of Medicine, New York, New York.
Alexander ShafferDivision of Infectious Diseases, Montefiore Medical Center/Albert Einstein College of Medicine, New York, New York.
Amie JohnDivision of Infectious Diseases, Montefiore Medical Center/Albert Einstein College of Medicine, New York, New York.
Wesley RogersDivision of Infectious Diseases, Weill Cornell Medicine, New York, New York.
Lars WestbladeDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.
Rebecca Marrero RolónDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.
Susan Madison-AntenucciParasitology Laboratory, New York State Department of Health, Albany, New York.
Phyu M ThweDepartment of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, New York, New York.
Erika OrnerDepartment of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, New York, New York.
Kerry MurphyDivision of Infectious Diseases, Montefiore Medical Center/Albert Einstein College of Medicine, New York, New York.
Grace A MaldarelliDivision of Infectious Diseases, Weill Cornell Medicine, New York, New York.
Laura KirkmanDivision of Infectious Diseases, Weill Cornell Medicine, New York, New York.
Johanna P DailyDivision of Infectious Diseases, Montefiore Medical Center/Albert Einstein College of Medicine, New York, New York.

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
T32: Pathogenesis of Infectious Diseases Training ProgramT32AI007613 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROY M. GULICK · 1999 to 2026
$8.8M
Defining the mechanism of coma in cerebral malariaR01AI164864 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Johanna Patricia Daily · 2022 to 2026
$2.7M
FIC NIH HHS D43 TW010540NIAID NIH HHS R01 AI164864NIAID NIH HHS T32 AI007613
6 · The paper itself

Abstract

We report two cases of recurrent malaria in U.S. travelers returning from Africa (Ghana and Central African Republic) despite a full course of artemether-lumefantrine (AL). Both patients presented to New York City hospitals, received AL treatment, and clinically improved. Within 2 weeks, they presented with recurrent Plasmodium falciparum malaria. Parasite isolates were sequenced, and P. falciparum kelch 13 propeller domain mutations that are validated or candidate markers of artemisinin partial resistance were not identified. Parasites had mutations within the P. falciparum multidrug resistance protein 1 gene. It is crucial to remain vigilant for recurrent malaria in travelers, even from African regions where partial resistance to artemisinin-based combination therapy has only rarely been reported.

Indexed as

AntimalarialsArtemisininsEthanolaminesFluorenesMalaria, FalciparumPlasmodium falciparumArtemether, Lumefantrine Drug CombinationDrug CombinationsHumansRecurrenceTravelUnited StatesAntimalarialsArtemether, Lumefantrine Drug CombinationArtemisininsDrug CombinationsEthanolaminesFluorenes

Identifiers

PMID39773552
PMCPMC11965738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.