Evidence map›Paper›PMID 39773551›Full record

ArticleInternational journal of retina and vitreous2025

Evaluating the reliability of a microperimetry-based method for assessing visual function in the junctional zone of geographic atrophy lesions.

A Yasin Alibhai, Eric M Moult, Muhammad Usman Jamil, Khadija Raza, Marco U Morales, Ramiro Ribeiro, Caroline R Baumal, James G Fujimoto, Nadia K Waheed

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In one paragraph

Article in International journal of retina and vitreous, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Geographic atrophy: Understanding the relationship between structure and function.Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

A Yasin Alibhai *Boston Image Reading Center, Boston, MA, USA.
Eric M Moult *Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Muhammad Usman JamilNew England Eye Center, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA.
Khadija RazaNew England Eye Center, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA.
Marco U MoralesApellis Pharmaceuticals, Waltham, MA, USA.
Ramiro RibeiroApellis Pharmaceuticals, Waltham, MA, USA.
Caroline R BaumalApellis Pharmaceuticals, Waltham, MA, USA.
James G FujimotoDepartment of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nadia K WaheedNew England Eye Center, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA. nadiakwaheed@gmail.com.

Funding

Novel Optical Diagnostics with Optical Coherence TomographyR01EY011289 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JAMES G FUJIMOTO · 1995 to 2026
$9.5M
NEI NIH HHS R01 EY011289NIH HHS R01EY011289
6 · The paper itself

Abstract

purposeTo assess the repeatability of a microperimetry methodology for quantifying visual function changes in the junctional zone of eyes with geographic atrophy (GA) in the clinical trial context.

methodsA post hoc analysis of the OAKS phase III trial was conducted, which enrolled patients with GA secondary to age-related macular degeneration. Microperimetry using a standard 10 - 2 fovea centered grid was performed at baseline and follow-up visits. GA regions were traced on fundus autofluorescence (FAF) images. Two graders independently registered baseline microperimetry images with baseline FAF images in a sampling of 30 eyes from the OAKS study. Agreement between the two graders' assessments of mean sensitivity and the number of scotomatous points within a ± 250 𝜇m GA junctional zone was assessed.

resultsThe intraclass correlation (ICC) and coefficient of repeatability (CoR) for the mean junctional zone sensitivity were 0.987 and 0.214 dB, respectively. The ICC and CoR for the total number of scotomatous points within the junctional zone were 0.991 and 1.42, respectively.

conclusionsThe repeatability of the methodology and its compatibility with standard MP acquisitions appear to make it well-suited for identifying and analyzing retinal sensitivity within high-risk areas of the retina. We present a microperimetry-based methodology for assessing visual function changes in the junctional zone of geographic atrophy lesions using a standard 10 - 2 fovea centered grid in a clinical trial context. The approach's repeatability and compatibility with standard microperimetry grids may make it useful for assessing the effects of GA therapeutics.

Indexed as

Age-related macular degenerationFundus auto fluorescenceGeographic atrophyMicroperimetryScotomatous points

Identifiers

PMID39773551
PMCPMC11707945

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.