ArticleEuropean journal of medical research2025
Whole transcriptome analysis and construction of gene regulatory networks of granulosa cells from patients with polycystic ovary syndrome (PCOS).
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The crosslink between autophagy and ferroptosis in polycystic ovary syndrome: from synergistic pathogenesis to targeted therapy.Journal of ovarian research · 2026Review
- Whole transcriptome sequencing to uncover CircRNA expression patterns linked to schizophrenia pathogenesis.European journal of medical research · 2025Article
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Authors and funding
4 authors.
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Abstract
objectivePolycystic ovary syndrome (PCOS) is a reproductive endocrine disease characterized by reproductive dysfunction and metabolic abnormalities. The purpose of this study was to explore the expression characteristics of coding and non-coding RNAs in granulosa cells of PCOS, and to provide data support for understanding the pathogenesis of PCOS.
methodsThree patients with PCOS (according to the 2003 Rotterdam diagnostic criteria) and three normal controls were selected. We used the standard long protocol to collect granulosa cells from two groups, who underwent assisted reproduction at the Reproductive Medicine Center of the Affiliated Hospital of Inner Mongolia Medical University, China. We performed whole-transcriptome sequencing using RNA-Seq technology to construct transcriptome patterns of messenger RNAs (mRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs). These patterns were then subjected to in-depth analysis using bioinformatics tools.
resultsWe identified a total of 2111 mRNAs and 4328 non-coding RNAs (ncRNAs) in the PCOS group as compared with the control group. Among the ncRNAs, there were 2047 lncRNAs, 892 circRNAs, and 1389 miRNAs. Based on the condition |log
conclusionIn this study, we discovered significant alterations in mRNAs, lncRNAs, circRNAs, and miRNAs in PCOS granulosa cells, indicating dysregulation in vital pathways. Notably, genes like VLDLR, PPP2R2B, and MYOCD, along with lncRNAs FBXO30, SNHG14, and PVT1, may contribute to PCOS pathology, shedding light on potential therapeutic targets.
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