ArticleeLife2025
Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease.
Abstract read
In one paragraph
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- tRNA modifications in viral replication.The Journal of biological chemistry · 2026Review
- A Novel Covalent Inhibitor Fragment for the SARS-CoV-2 Main Protease Identified by Target-Specific Deep Learning.ACS chemical biology · 2026Article
- Unbiased cleavage site prediction uncovers viral antagonism of host innate immunity by SARS-CoV-2 3C-like protease.JCI insight · 2026Article
- Multi-Component Synthesis of New Fluorinated-Pyrrolo[3,4-International journal of molecular sciences · 2025Article
- The coronavirus 3CL protease: Unveiling its complex host interactions and central role in viral pathogenesis.Virologica Sinica · 2025Review
- Bi-allelic pathogenic variants in TRMT1 disrupt tRNA modification and induce a neurodevelopmental disorder.American journal of human genetics · 2025Article
- SARS-CoV-2 Displays a Suboptimal Codon Usage Bias for Efficient Translation in Human Cells Diverted by Hijacking the tRNA Epitranscriptome.International journal of molecular sciences · 2024Article
- Methylation modifications in tRNA and associated disorders: Current research and potential therapeutic targets.Cell proliferation · 2024Review
- RNA modifying enzymes shape tRNA biogenesis and function.The Journal of biological chemistry · 2024Review
- High-Resolution Substrate Specificity Profiling of SARS-CoV-2 MACS chemical biology · 2024Article
- Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease.eLife · 2024Article
- Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease.bioRxiv : the preprint server for biology · 2024Article
- OrthoMaM v12: a database of curated single-copy ortholog alignments and trees to study mammalian evolutionary genomics.Nucleic acids research · 2024Article
- SARS-CoV-2 main protease Nsp5 cleaves and inactivates human tRNA methyltransferase TRMT1.Journal of molecular cell biology · 2023Article
- The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections.Frontiers in genetics · 2023Review
Corrections and comments
- Update of
Authors and funding
8 authors.
Angel D'OlivieraDepartment of Chemistry & Biochemistry, University of Delaware, Newark, United States.ORCID https://orcid.org/0000-0002-5944-9609
Xuhang DaiDepartment of Chemistry, New York University, New York, United States.ORCID https://orcid.org/0009-0007-6712-8737
Saba MottaghiniaCIRI (Centre International de Recherche en Infectiologie), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.ORCID https://orcid.org/0000-0002-9409-3302
Sophie OlsonDepartment of Chemistry & Biochemistry, University of Delaware, Newark, United States.
Evan P GeisslerDepartment of Chemistry & Biochemistry, University of Delaware, Newark, United States.
Lucie EtienneCIRI (Centre International de Recherche en Infectiologie), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.ORCID https://orcid.org/0000-0002-8585-7534
Yingkai ZhangDepartment of Chemistry, New York University, New York, United States.ORCID https://orcid.org/0000-0002-4984-3354
Jeffrey S MugridgeDepartment of Chemistry & Biochemistry, University of Delaware, Newark, United States.ORCID https://orcid.org/0000-0002-1553-3008
Funding
This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2014 to 2024
$26.8MComputational modulator design and machine learning to target protein-protein interactionsR35GM127040 · NIGMS · NEW YORK UNIVERSITY · PI Yingkai Zhang · 2018 to 2026
$4.6MChemistry-Biology Interface Predoctoral Training Grant 2024-2029T32GM133395 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine Leimkuhler Grimes · 2019 to 2026
$3.7MSelectivity and regulation of mRNA demethylation by iron-dependent dioxygenasesR35GM143000 · NIGMS · UNIVERSITY OF DELAWARE · PI MUGRIDGE, JEFFREY SCOTT · 2021 to 2025
$2.1MAgence Nationale de la Recherche ANR-20-CE15-0020-01French Research Agency on HIV and Emerging Infectious Diseases ANRS/MIE ECTZ118944NIGMS NIH HHS R35 GM127040NIGMS NIH HHS R35 GM143000NIGMS NIH HHS T32 GM133395NIH HHS P20 GM104316NIH HHS R35 GM127040NIH HHS R35 GM143000NIH HHS S10 OD026896ANIH HHS T32 GM133395
Abstract
The SARS-CoV-2 main protease (M
Indexed as
Coronavirus 3C ProteasesSARS-CoV-2tRNA MethyltransferasesCOVID-19HEK293 CellsHumansProtein BindingProteolysisRNA, Transfer3C-like proteinase, SARS-CoV-2Coronavirus 3C ProteasesRNA, TransfertRNA Methyltransferasesbiochemistrychemical biologyhost-virus interactionshumanmolecular biophysicsproteaseRNA-protein interactionsstructural biologytRNA modifications
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.