ArticleBMC pediatrics2025
Epidemiology and clinical features of childhood malignant solid tumors in a single center in southwest China over 24 years.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Sleep-related symptoms and cognitive fatigue are prominent in the multidimensional symptom network of children with malignant solid tumors: key targets and subgroup differences.BMC psychology · 2026Article
- Neuroblastoma treatment in children: Single-center case series and review of the literature.Turkish journal of surgery · 2026Article
- Current Strategies for Limb Salvage and Reconstruction in Pediatric Lower Extremity Malignant Bone Tumors: Focus on Growth Preservation and Functional Outcomes.Children (Basel, Switzerland) · 2025Review
- Immunometabolic Gatekeeping: Reconciling Peto's & the T-cell Infiltration Prognostic Paradox.ArXiv · 2025Article
- A case report: pediatric rhabdomyosarcoma presenting with bone marrow metastasis.BMC pediatrics · 2025Article
- Lipid metabolism abnormalities in pediatric abdominal solid malignant tumors: a comprehensive review.Frontiers in pediatrics · 2025Review
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3 authors.
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Abstract
objectiveThis study aims to analyze the epidemiological characteristics and clinical features of childhood malignant solid tumors in a single center in southwest China, thereby providing a reliable basis for formulating prevention and control strategies and rational allocation of resources for these tumors.
methodsChildren less than 15 years old and under-diagnosed with malignant solid tumors for the first time at Children's Hospital of Chongqing Medical University (Children's Medical Center of Southwest China) from 2000 to 2023 were selected. They were classified according to the International Classification of Childhood Cancer, Third Edition (ICCC-3). A retrospective analysis was conducted on the disease spectrum composition and trends, distribution among different age groups and genders, and hospitalization characteristics of the patients.
resultsOver 24 years, there were a total of 4,777 cases of initial diagnosis of childhood malignant solid tumors, with a male-to-female ratio of 1.33:1. The median age was 4 years old, with 12.6% in the 0-year-old group, 41.6% in the 1 to 4-year-old group, 27.3% in the 5 to 9-year-old group, and 18.5% in the 10 to 14-year-old group. The top 3 malignant solid tumors by incidence rate were central nervous system (CNS) tumors (21.8%), neuroblastoma (17.8%), and lymphoma (13.9%). The ratio of pediatric malignant solid tumor patients to total hospital admissions rose from 0.14% in 2000 to 0.52% in 2021 but showed a declining trend after 2021. Childhood malignant solid tumors were primarily diagnosed due to the discovery of mass/occupancy (34.9%), abdominal pain/bloating (21.1%), or fever (6.3%). 74.4% of neuroblastomas and 54.7% of nephroblastomas were diagnosed at an advanced stage. 84.4% of patients underwent surgery, and 71.9% received chemotherapy, with chemotherapy rates showing an upward trend.
conclusionsThis study provides reliable information on the incidence characteristics and trends of childhood malignant solid tumors.
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