Evidence map›Paper›PMID 39773361›Full record

ReviewStem cell research & therapy2025

Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies.

Amirata Mohseni, Fatemeh Salehi, Samaneh Rostami, Kaveh Hadiloo, Mehrdad Hashemi, Zahra Baridjavadi, Fatemeh Ahangari, Najibeh Karami, Fatemeh Samani, Safa Tahmasebi and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. The Significance of the Microenvironment in T/Nk-Cell Neoplasms.International journal of molecular sciences · 2025
    Review
  6. Review
  7. Review
  8. Review
  9. Extracellular Vesicle Lipids and Their Role in Delivery.Journal of extracellular biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Amirata Mohseni *Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Fatemeh Salehi *Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Samaneh RostamiSchool of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Kaveh HadilooSchool of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Mehrdad HashemiFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Zahra BaridjavadiDepartment of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Fatemeh AhangariDepartment of Immunology, Pasteur Institue of Iran, Tehran, Iran.
Najibeh KaramiHematology-Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh SamaniBlood Transfusion Research Center, High Institute for Research and Education in transfusion medicine, Iranian Blood Transfusion Organization (IBTO), Tehran, Iran.
Safa TahmasebiStudent Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. safa.tahmasebi@sbmu.ac.ir.ORCID https://orcid.org/0000-0002-8598-1922
Najma FarahaniFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. najmafarahani@yahoo.com.
Afshin TaheriazamDepartment of Orthopedics, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. a.taheriazam@iautmu.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are small extracellular vesicles of endocytic origin released by various cell types. They consist of lipid bilayers containing macromolecules such as lipids, proteins, microRNAs, growth factors, cytokines, and carbohydrates. Exosomes play a critical role in the diagnosis and treatment of various diseases. For instance, exosome contents have been utilized as biomarkers in body fluids (urine, saliva, serum) to identify cancers, autoimmune diseases, and inflammatory conditions such as sepsis. Due to their small size and ability to reach tumor microenvironments, exosomes are also used as carriers for chemotherapeutic drugs in drug delivery systems. Furthermore, evidence indicates that malignant cells release exosomes into the tumor microenvironment, influencing immune cells in a paracrine manner. Additionally, immune cell-derived exosomes, such as those from Natural Killer (NK) cells or cytotoxic T lymphocytes (CTLs), show potential as therapeutic agents in treating malignancies like leukemia. This review discusses the diagnostic role of exosomes in various hematological malignancies and explores the therapeutic potential of immune cell-derived exosomes in these diseases.

Indexed as

ExosomesHematologic NeoplasmsBiomarkers, TumorHumansPrognosisTumor MicroenvironmentBiomarkers, TumorExosomesHematological malignanciesMicroRNAsSmall extracellular vesiclesStem cell

Identifiers

PMID39773361
PMCPMC11708188

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.