Evidence map›Paper›PMID 39773168›Full record

ArticleAmerican journal of respiratory cell and molecular biology2025

TGF-β Receptor-dependent Tissue Factor Release and Proteomic Profiling of Extracellular Vesicles from Mechanically Compressed Human Bronchial Epithelial Cells.

Chimwemwe Mwase, Stephen A Schworer, Rodney C Gilmore, Faria Khan, Alane Blythe C Dy, Adam L Haber, Richard C Boucher, Scott H Randell, Nigel Mackman, Jin-Ah Park

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Chimwemwe MwaseDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.
Stephen A SchworerMarsico Lung Institute and.ORCID 0000-0001-7741-8972
Rodney C GilmoreMarsico Lung Institute and.
Faria KhanDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.
Alane Blythe C DyDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.ORCID 0000-0002-9899-6090
Adam L HaberDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.
Richard C BoucherMarsico Lung Institute and.
Scott H RandellMarsico Lung Institute and.
Nigel MackmanUNC Blood Research Center, Division of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Jin-Ah ParkDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.ORCID 0000-0002-8930-9287

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Scott H Randell · 2004 to 2026
$26.5M
Training Program in Molecular and Integrative Physiological SciencesT32HL007118 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LU, QUAN · 1985 to 2025
$14.3M
CTSA K12 Program at UNCK12TR004416 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michelle Hernandez, Jonathan J Juliano · 2023 to 2026
$6.5M
Tissue factor-dependent coagulation in thrombosis and immune responsesR35HL155657 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Nigel Mackman · 2021 to 2026
$5.5M
Physics of bronchial epithelial unjammingR01HL148152 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J, PARK, JIN-AH · 2019 to 2022
$2.2M
Cystic Fibrosis Foundation BOUCHE19R0Fujifilm CorporationJohn C. Parker ProfessorshipNCATS NIH HHS K12 TR004416NHLBI NIH HHS R01 HL148152NHLBI NIH HHS R35 HL155657NHLBI NIH HHS T32 HL007118NIDDK NIH HHS P30 DK065988NIEHS NIH HHS P30 ES000002NIH HHS 1K12TR004416
6 · The paper itself

Abstract

In asthma, tissue factor (TF) concentrations are elevated in the lung. In our previous studies using mechanically compressed human bronchial epithelial (HBE) cells, which are a well-defined

Indexed as

AsthmaBronchiEpithelial CellsExtracellular VesiclesProteomicsReceptors, Transforming Growth Factor betaThromboplastinAdultFemaleHumansMaleMiddle AgedReceptors, Transforming Growth Factor betaThromboplastinasthma exacerbationsepithelial compressionextracellular vesiclesTGF-βtissue factor

Identifiers

PMID39773168
PMCPMC12254691

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.