Evidence map›Paper›PMID 39773038›Full record

ArticleRecent patents on anti-cancer drug discovery2026

Differential Expression and Distribution of Slco4a1 and Slco1b2 in an Internal Environment Disorder-induced Hepatocellular Carcinoma Mouse Model.

Haoxuan Luo, Yang Xie, Shan Huang, Yu Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Recent patents on anti-cancer drug discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Haoxuan LuoSchool of Traditional Chinese Medicine, Chongqing Medical and Pharmaceutical College, Chongqing, 401331, China.
Yang XieSchool of Clinic Medicine, Chongqing Medical and Pharmaceutical College, Chongqing, 401331, China.
Shan HuangSchool of Traditional Chinese Medicine, Chongqing Medical and Pharmaceutical College, Chongqing, 401331, China.
Yu ZhangSchool of Traditional Chinese Medicine, Chongqing Medical and Pharmaceutical College, Chongqing, 401331, China.

Funding

Chongqing Traditional Chinese Medicine Technology Innovation and Application Development Project (Joint project of Chongqing Health Commission and Science and Technology Bureau) 2020ZY3634Educational Reform Project of Chongqing Medical and Pharmaceutical College CQYGZJG2203Natural Science Foundation of Chongqing Medical and Pharmaceutical College Ygz2021103Scientific and Technological Research Program of Chongqing Municipal Education Commission KJQN202302838, KJQN202202828Sichuan-Chongqing Key Laboratory of Chinese and Western Integrative Medicine for Spinal-related Diseases ygz2021501
6 · The paper itself

Abstract

objectiveThis study aims to enhance the understanding of underlying mechanisms and potential therapies of the solute carrier organic anion (SLCO) transporter family in internal environment disorder (IED)-induced hepatocellular carcinoma (HCC). This could lead to new therapeutic strategies and offer new directions for the creation of new patents for HCC treatment products.

methodsThe orthotopic transplantation (OT), IED and IED-based OT (IED-OT) mouse models were established. Expression patterns of Slco4a1 and Slco1b2 were determined using reverse transcription quantitative polymerase chain reaction (RT-qPCR), western blotting (WB) and immunohistochemistry (IHC) in various tissues, including lung, stomach, liver, spleen, kidney, colon, small intestine, HCC tissues and adjacent non-cancerous tissues.

resultsAnimals exhibited symptoms, including weight loss, lethargy, chills, dyspnea, altered hair texture, and gastrointestinal disturbances, confirming the successful establishment of the IED model. The analysis demonstrated differential expression and tissue-specific distribution of Slco4a1 and Slco1b2, which are associated with IED-induced changes. These alterations potentially disrupt organ transport functions, thereby promoting the development of HCC. Additionally, they suggest a role in rebalancing the tumor microenvironment and mitigating damage resulting from abnormal substance accumulation. DISCUSSION: This study reveals that IED promotes HCC progression by altering the expression and distribution of Slco4a1 and Slco1b2, leading to transport dysfunction in affected organs. Furthermore, IED and OT exhibit synergistic effects in HCC development. These findings enhance the understanding of the underlying mechanisms of IED related HCC. Future studies should establish animal models incorporating both internal and external factors, with cellular experiments needed to further validate the mechanisms.

conclusionChanges in SLCO expression and distribution induced by IED may play pivotal roles in the development of HCC. These findings contribute insights that could inform novel therapeutic strategies against HCC.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsOrganic Anion TransportersAnimalsDisease Models, AnimalHumansLiver-Specific Organic Anion Transporter 1MaleMiceOrganic Cation Transport ProteinsPatents as TopicLiver-Specific Organic Anion Transporter 1Organic Anion TransportersOrganic Cation Transport ProteinsSLCO1A1 protein, mouseSlco1b2 protein, mouseexpression patternHepatocellular carcinomainternal environment disorderSlco1b2Slco4a1SLCO transporters

Identifiers

PMID39773038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.