Evidence map›Paper›PMID 39773028›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Mutational analysis of an antimalarial drug target,

Swaksha Rachuri, Binod Nepal, Anurag Shukla, Aarti Ramanathan, Joanne M Morrisey, Thomas Daly, Michael W Mather, Lawrence W Bergman, Sandhya Kortagere, Akhil B Vaidya

Erratum issuedAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Swaksha Rachuri *Department of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA 19129.ORCID 0009-0001-4290-9795
Binod Nepal *Department of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA 19129.
Anurag Shukla *Department of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA 19129.ORCID 0000-0003-4035-2978
Aarti RamanathanDepartment of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA 19129.
Joanne M MorriseyDepartment of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA 19129.ORCID 0009-0009-7463-3365
Thomas DalyDepartment of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA 19129.
Michael W MatherDepartment of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA 19129.ORCID 0000-0002-1062-0137
Lawrence W BergmanDepartment of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA 19129.
Sandhya KortagereDepartment of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA 19129.ORCID 0000-0002-3532-8669
Akhil B VaidyaDepartment of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA 19129.ORCID 0000-0003-1063-5571

Funding

Molecular Pathways Affected by Drugs that Disrupt Na+ Homeostasis in Malaria ParasitesR01AI132508 · NIAID · DREXEL UNIVERSITY · PI AKHIL B VAIDYA · 2017 to 2026
$5.7M
Advancing Fast-acting Antimalarials that Disrupt Na+ Homeostasis in ParasitesR01AI154499 · NIAID · DREXEL UNIVERSITY · PI KORTAGERE, SANDHYA, VAIDYA, AKHIL B · 2020 to 2024
$3.7M
Breakthrough Molecular Dynamics Research via an Anton2 SupercomputerR01GM116961 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D. · 2016 to 2023
$3.0M
Anton 2 Award MCB210021PHHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI132508HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI154499HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM116961NIAID NIH HHS R01 AI132508NIAID NIH HHS R01 AI154499NIGMS NIH HHS R01 GM116961
6 · The paper itself

Abstract

Among new antimalarials discovered over the past decade are multiple chemical scaffolds that target

Indexed as

AntimalarialsPlasmodium falciparumCalcium-Transporting ATPasesDNA Mutational AnalysisDrug ResistanceHumansMalaria, FalciparumModels, MolecularMolecular Dynamics SimulationMutationProtozoan ProteinsP-type ATPasesAntimalarialsCalcium-Transporting ATPasesProtozoan ProteinsP-type ATPasesantimalarial drugsmalariamolecular dynamicsmutagenesisP-type ATPases

Identifiers

PMID39773028
PMCPMC11745376

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.