Evidence map›Paper›PMID 39773021›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Engaging dystonia networks with subthalamic stimulation.

Konstantin Butenko, Clemens Neudorfer, Till A Dembek, Barbara Hollunder, Garance M Meyer, Ningfei Li, Simón Oxenford, Bahne H Bahners, Bassam Al-Fatly, Roxanne Lofredi and 11 more

Abstract readMulticenter Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Beyond the Homunculus-SCAN-AMN as a Shared Action-Oriented Neural Substrate across Movement Disorders.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Optimal Deep Brain Stimulation Locations for Gilles de la Tourette Syndrome.medRxiv : the preprint server for health sciences · 2026
    Article
  11. Distinct Roles of Cerebellar Afferent and Efferent Fiber Tracts in Craniocervical Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. A Multi-Symptom Circuit Architecture of Obsessive-Compulsive Disorder.medRxiv : the preprint server for health sciences · 2025
    Article
  17. Somato-Cognitive Action Network in Focal Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  18. Review
  19. Engaging dystonia networks with subthalamic stimulation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Konstantin ButenkoCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-4509-4624
Clemens NeudorferCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115.
Till A DembekDepartment of Neurology, Faculty of Medicine, University of Cologne, Cologne 50937, Germany.
Barbara HollunderMovement Disorders and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin 10117, Germany.ORCID 0000-0003-0104-6927
Garance M MeyerCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115.
Ningfei LiMovement Disorders and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin 10117, Germany.ORCID 0000-0003-3315-3591
Simón OxenfordMovement Disorders and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin 10117, Germany.ORCID 0000-0003-2989-3861
Bahne H BahnersCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115.
Bassam Al-FatlyMovement Disorders and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin 10117, Germany.ORCID 0000-0003-0067-6177
Roxanne LofrediMovement Disorders and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin 10117, Germany.ORCID 0000-0002-1845-8250
Evan M GordonMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-2276-5237
Nico U F DosenbachMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.
Christos GanosMovement Disorder Clinic, Edmond J. Safra Program in Parkinson's Disease, Division of Neurology, University of Toronto, Toronto Western Hospital, Toronto, ON M5T 2S6, Canada.
Mark HallettHuman Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.ORCID 0000-0002-3180-6811
Hyder A JinnahDepartment of Neurology, Emory University, Atlanta, GA 30322.ORCID 0000-0003-1531-3969
Philip A StarrDepartment of Neurological Surgery, University of California, San Francisco, CA 94143.
Jill L OstremMovement Disorders and Neuromodulation Centre, Department of Neurology, University of California, San Francisco, CA 94143.
Yiwen WuDepartment of Neurology & Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.ORCID 0000-0001-6059-7054
ChenCheng ZhangDepartment of Neurosurgery, Rujin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.ORCID 0000-0003-4472-4134
Michael D FoxCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115.
Andreas HornCenter for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115.

Funding

BRAIN CONNECTS: The center for Large-scale Imaging of Neural Circuits (LINC)UM1NS132358 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Suzanne N Haber, Elizabeth M. C. Hillman · 2023 to 2026
$17.5M
Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptomsR01MH113929 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2017 to 2026
$6.9M
Toward Connectomic Deep Brain Stimulation in Obsessive Compulsive DisorderR01MH130666 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.9M
Using Brain Lesions and Deep Brain Stimulation to Identify an Epilepsy CircuitR01NS127892 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2022 to 2026
$3.4M
Transdiagnostic memory, mood and motor circuits in Alzheimer's and neurodegenerative diseaseR56AG069086 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI FOX, MICHAEL D · 2021 to 2021
$873k
Targeted modulation of symptom-specific brain circuits with transcranial magnetic stimulationR21MH126271 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI FOX, MICHAEL D · 2021 to 2022
$492k
Identifying neuromodulation targets for pain in the human brainR21NS123813 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI FOX, MICHAEL D · 2022 to 2023
$492k
Foundation for the National Institutes of Health (FNIH) 1R01NS127892-01Foundation for the National Institutes of Health (FNIH) 2R01 MH113929Foundation for the National Institutes of Health (FNIH) R01 13478451Foundation for the National Institutes of Health (FNIH) UM1NS132358New Venture Fund (NVF) FFOR Seed GrantNIA NIH HHS R56 AG069086NIMH NIH HHS R01 MH113929NIMH NIH HHS R01 MH130666NIMH NIH HHS R21 MH126271NINDS NIH HHS R01 NS127892NINDS NIH HHS R21 NS123813NINDS NIH HHS UM1 NS132358
6 · The paper itself

Abstract

Deep brain stimulation is an efficacious treatment for dystonia. While the internal pallidum serves as the primary target, recently, stimulation of the subthalamic nucleus (STN) has been investigated. However, optimal targeting within this structure and its surroundings have not been studied in depth. Indeed, historical targets that have been used for surgical treatment of dystonia are directly adjacent to the STN. Further, multiple types of dystonia exist, and outcomes are variable, suggesting that not all types would profit maximally from the same target. Therefore, a thorough investigation of neural substrates underlying stimulation effects on dystonia signs and symptoms is warranted. Here, we analyze a multicenter cohort of isolated dystonia patients with subthalamic implantations (

Indexed as

Deep Brain StimulationDystoniaSubthalamic NucleusAdultAgedBlepharospasmFemaleHumansMaleMiddle AgedNerve NetTorticollisTreatment Outcomecervical dystoniadeep brain stimulationlimb dystoniastructural connectivitysweet-spot analysis

Identifiers

PMID39773021
PMCPMC11745339

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.