ArticleScience translational medicine2025
Targeting the CD74 signaling axis suppresses inflammation and rescues defective hematopoiesis in
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Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Genetic influences on haematopoiesis.Nature reviews. Genetics · 2026Review
- Review
- Thymic alveolar type 2 epithelial mimetic cells revealed by RUNX1 deficiency.Nature immunology · 2026Article
- Telomere attrition is common in patients with germlineHaematologica · 2026Article
- Exercise Attenuates Aortic Dissection Via PDE5A-Mediated Inhibition of Vascular Smooth Muscle Cell Phenotypic Switch.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Lineage-specific CK2α deletion reshapes the transcriptome of hematopoietic stem cells toward an immune-primed state.bioRxiv : the preprint server for biology · 2026Article
- TNF-α signaling drives myeloid skewing and clonal expansion of stem and progenitor cells inHaematologica · 2026Article
- CDK4/6 inhibition overcomes venetoclax resistance mechanisms with enhanced combination activity in acute myeloid leukemia.Cell reports. Medicine · 2026Article
- Review
- The Dual Role of RUNX1 in Inflammation-Driven Age-Related Diseases: From Molecular Mechanisms to Clinical Translation.Biomedicines · 2025Review
- GATA2 decommissioning of enhancers: A mechanism to constrain inflammatory signaling.Cell reports · 2025Article
- Hereditary Hematopoietic Malignancies: Considerations for Optimizing Diagnosis and Management.Current oncology reports · 2025Review
- Closing the loop: Teaching single-cell foundation models to learn from perturbations.bioRxiv : the preprint server for biology · 2025Article
- Post-translational modifications orchestrate mTOR-driven cell death in cardiovascular disease.Frontiers in cardiovascular medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Mona MohammadhosseiniKnight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0002-5643-6052
Trevor EnrightKnight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0009-0006-4367-2386
Adam DuvallDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-9163-8792
Alex ChitsazanKnight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Hsin-Yun LinKnight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0002-6322-1826
Aysegul OrsKnight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0003-2325-5404
Brett A DavisKnight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0001-7985-1921
Olga NikolovaKnight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Erica BrescianiOncogenesis and Development Section, Division of Intramural Research, National Human Genome Research Institute, Bethesda, MD 20894, USA.
Jamie DiemerOncogenesis and Development Section, Division of Intramural Research, National Human Genome Research Institute, Bethesda, MD 20894, USA.
Kathleen CraftOncogenesis and Development Section, Division of Intramural Research, National Human Genome Research Institute, Bethesda, MD 20894, USA.
Ana Catarina MenezesOncogenesis and Development Section, Division of Intramural Research, National Human Genome Research Institute, Bethesda, MD 20894, USA.ORCID 0000-0002-3386-1910
Matthew MerguerianOncogenesis and Development Section, Division of Intramural Research, National Human Genome Research Institute, Bethesda, MD 20894, USA.ORCID 0000-0001-8294-5961
Shawn ChongOncogenesis and Development Section, Division of Intramural Research, National Human Genome Research Institute, Bethesda, MD 20894, USA.ORCID 0009-0007-2174-8236
Katherine R CalvoDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Natalie T DeuitchOncogenesis and Development Section, Division of Intramural Research, National Human Genome Research Institute, Bethesda, MD 20894, USA.ORCID 0000-0002-0146-1162
Shira Glushakow-SmithAlbert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0002-6012-7236
Kira GritsmanAlbert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0002-1367-1167
Lucy A GodleyDivision of Hematology/Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Marshall S HorwitzDepartment of Laboratory Medicine & Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-1683-1680
Sioban KeelDepartment of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-9599-8226
Lucio H CastillaDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.ORCID 0000-0002-7450-758X
Emek DemirKnight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0002-3663-7113
Hisham MohammedKnight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Paul LiuOncogenesis and Development Section, Division of Intramural Research, National Human Genome Research Institute, Bethesda, MD 20894, USA.ORCID 0000-0002-6779-025X
Anupriya AgarwalKnight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0002-8319-6162
Funding
LAB RESEARCH TRAINING IN PEDIATRIC ONCOLOGY-HEMATOLOGYT32CA060441 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN D FRIEDMAN · 1993 to 2026
$14.9MRegulation and function of hematopoietic stem cell nichesR01DK056638 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GRITSMAN, KIRA · 2000 to 2023
$8.7MInflammation-Driven Clonal Evolution in RUNX1 Carriers: Mechanisms and Therapeutic VulnerabilitiesR01HL155426 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Anupriya Agarwal · 2021 to 2026
$2.7MThe role of inflammation in driving leukemogenesis in germline predisposition syndromesU01CA257666 · NCI · UNIVERSITY OF CHICAGO · PI AGARWAL, ANUPRIYA, BRESNICK, EMERY H. · 2022 to 2025
$2.5MPI3 Kinase Inactivation in Myelodysplastic SyndromeR01DK130895 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI GRITSMAN, KIRA · 2022 to 2025
$2.2MIntegrated Training in Quantitative and Experimental Cancer Systems BiologyT32CA254888 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Sudarshan Anand, LISA M COUSSENS · 2021 to 2026
$2.2MStudying drug resistance in AML and PDAC using a novel heterotypic 3D organoid modelR01CA229875 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI AGARWAL, ANUPRIYA · 2019 to 2023
$1.6MCross-talk mechanisms between RUNX1 and inflammatory signals impacting functions of stem and progenitors in Familial Platelet Disorder.F31HL162542 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI MOHAMMADHOSSEINI, MONA · 2022 to 2024
$143kNCI NIH HHS R01 CA229875NCI NIH HHS T32 CA060441NCI NIH HHS T32 CA254888NCI NIH HHS U01 CA257666NHLBI NIH HHS F31 HL162542NHLBI NIH HHS R01 HL155426NIDDK NIH HHS R01 DK056638NIDDK NIH HHS R01 DK130895
Abstract
Familial platelet disorder (FPD) is associated with germline
Indexed as
Blood Platelet DisordersCore Binding Factor Alpha 2 SubunitHematopoiesisInflammationSignal TransductionAnimalsBlood Coagulation Disorders, InheritedCell DifferentiationCytokinesHematopoietic Stem CellsHumansLeukemia, Myeloid, AcuteMiceTOR Serine-Threonine KinasesCore Binding Factor Alpha 2 SubunitCytokinesRUNX1 protein, humanTOR Serine-Threonine Kinases
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.