ArticleProceedings of the National Academy of Sciences of the United States of America2025
Exome sequencing identifies genes for socioeconomic status in 350,770 individuals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- On the relationship between genes and environment.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reply to Hirbo et al.: The need for large-scale family cohorts and robust analytical frameworks of postexome study.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genetic associations with socioeconomic status are limited in explaining the socioeconomic health gradient.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reply to Füller et al.: Exome-wide genetic associations with socioeconomic status and their pleiotropy among health outcomes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Socioeconomic status (SES) is a critical factor in determining health outcomes and is influenced by genetic and environmental factors. However, our understanding of the genetic structure of SES remains incomplete. Here, we conducted a large-scale exome study of SES markers (household income, occupational status, educational attainment, and social deprivation) in 350,770 individuals. For rare coding variants, we identified 56 significant associations by gene-based collapsing tests, unveiling 7 additional SES-associated genes (
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