Evidence map›Paper›PMID 39772670›Full record

ArticleScience advances2025

Differential encoding of mammalian proprioception by voltage-gated sodium channels.

Cyrrus M Espino, Chetan Nagaraja, Serena Ortiz, Jacquelyn R Dayton, Akash R Murali, Yanki Ma, Emari L Mann, Snigdha Garlapalli, Ross P Wohlgemuth, Sarah E Brashear and 3 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Cyrrus M EspinoDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-2708-4577
Chetan NagarajaDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.ORCID 0000-0001-9768-9462
Serena OrtizDepartment of Biological Sciences, San José State University, San Jose, CA, USA.
Jacquelyn R DaytonDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.
Akash R MuraliDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.ORCID 0009-0001-2438-4497
Yanki MaDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-6135-8298
Emari L MannDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.ORCID 0009-0000-5110-1555
Snigdha GarlapalliDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.
Ross P WohlgemuthDepartment of Physiology, Neurobiology, and Behavior, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-1841-2148
Sarah E BrashearDepartment of Physiology, Neurobiology, and Behavior, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-4601-3520
Lucas R SmithDepartment of Physiology, Neurobiology, and Behavior, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-7610-4231
Katherine A WilkinsonDepartment of Biological Sciences, San José State University, San Jose, CA, USA.ORCID 0000-0002-2692-5533
Theanne N GriffithDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-0090-6286

Funding

VISION RESEARCH CORE GRANTP30EY012576 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI W MARTIN USREY · 1999 to 2026
$18.9M
Postbaccalaureate Research Education Program at UC DavisR25GM116690 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOANNA Chungyen CHIU · 2017 to 2026
$3.7M
Initiative for Maximizing Student Development at the University of California, Davis.T32GM135741 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ALDRIN V. GOMES, Manuel F Navedo · 2020 to 2026
$3.2M
Interdependency of fibroadipogenic progenitors and extracellular matrix that drive skeletal muscle fibrosisR01AR079545 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LUCAS R SMITH · 2022 to 2026
$2.5M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
Training Program in PharmacologyT32GM144303 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, JOHANNES W HELL · 2022 to 2026
$2.1M
The electrical basis of proprioceptive signalingR01NS135005 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Theanne Nicole Griffith · 2024 to 2026
$1.4M
UC Davis Advancing Diversity in the Neuroscience Research (ADNR) ProgramR25NS112130 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI USREY, W MARTIN · 2019 to 2023
$1.2M
A Novel Role for Nav1.1 in Mammalian ThermosensationK01NS124828 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Theanne Nicole Griffith · 2022 to 2026
$982k
Molecular mediators of muscle spindle mechanosensationR16GM153600 · NIGMS · SAN JOSE STATE UNIVERSITY · PI Katherine Anne Wilkinson · 2024 to 2026
$440k
The encoding of proprioceptive signaling by Nav1.6F31NS134241 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ESPINO, CYRRUS MAXWELL · 2024 to 2025
$65k
Using collagenase to target collagen architecture in fibrotic skeletal muscle to reduce stiffness and promote tissue regeneration.F31AR082695 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WOHLGEMUTH, ROSS PAUL · 2024 to 2024
$28k
NEI NIH HHS P30 EY012576NIAMS NIH HHS F31 AR082695NIAMS NIH HHS R01 AR079545NIGMS NIH HHS R16 GM153600NIGMS NIH HHS R25 GM116690NIGMS NIH HHS T32 GM099608NIGMS NIH HHS T32 GM135741NIGMS NIH HHS T32 GM144303NINDS NIH HHS F31 NS134241NINDS NIH HHS K01 NS124828NINDS NIH HHS R01 NS135005NINDS NIH HHS R25 NS112130
6 · The paper itself

Abstract

Animals requiring purposeful movement for survival are endowed with mechanoreceptors, called proprioceptors, that provide essential sensory feedback from muscles and joints to spinal cord circuits, which modulates motor output. Despite the essential nature of proprioceptive signaling in daily life, the mechanisms governing proprioceptor activity are poorly understood. Here, we identified nonredundant roles for two voltage-gated sodium channels (Na

Indexed as

Mice, KnockoutNAV1.6 Voltage-Gated Sodium ChannelProprioceptionAnimalsMiceMuscle, SkeletalNAV1.1 Voltage-Gated Sodium ChannelVoltage-Gated Sodium ChannelsNAV1.1 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelScn8a protein, mouseVoltage-Gated Sodium Channels

Identifiers

PMID39772670
PMCPMC11708877

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.