Evidence map›Paper›PMID 39772668›Full record

ArticleScience advances2025

Tgfβ signaling stimulates glycolysis to promote the genesis of synovial joint interzone in developing mouse embryonic limbs.

Chao Song, Jasmin Koehnken Sawall, Xing Ji, Fangfang Song, Xueyang Liao, Renpeng Peng, Hao Ren, Eiki Koyama, Maurizio Pacifici, Fanxin Long

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chao SongTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-1209-1056
Jasmin Koehnken SawallTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0009-0005-2750-8108
Xing JiTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0009-0002-5794-6078
Fangfang SongTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-9465-6083
Xueyang LiaoTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-7876-3129
Renpeng PengDepartment of Orthopedic Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Hao RenDepartment of Orthopedic Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Eiki KoyamaTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-6030-6384
Maurizio PacificiTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-6854-4942
Fanxin LongTranslational Research Program in Pediatric Orthopedics, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0001-9785-5379

Funding

The cell metabolism basis for bone complications in type I diabetesR01DK125498 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI LONG, FANXIN · 2021 to 2024
$1.8M
Regulation of limb synovial joint organization and functionR21AR081419 · NIAMS · CHILDREN'S HOSP OF PHILADELPHIA · PI PACIFICI, MAURIZIO · 2022 to 2023
$426k
NIAMS NIH HHS R21 AR081419NIDDK NIH HHS R01 DK125498
6 · The paper itself

Abstract

The initial interzone cells for synovial joints originate from chondrocytes, but such critical transition is minimally understood. With single-cell RNA sequencing (scRNA-seq) of murine embryonic knee joint primordia, we discovered that heightened expression of glycolysis genes characterized developing interzone cells when compared to flanking chondrocytes. Conditional deletion of the glucose transporters

Indexed as

ChondrocytesGlucose Transporter Type 1Glucose Transporter Type 3GlycolysisSignal TransductionTransforming Growth Factor betaAnimalsEmbryo, MammalianHomeodomain ProteinsHypoxia-Inducible Factor 1, alpha SubunitMiceTOR Serine-Threonine KinasesGlucose Transporter Type 1Glucose Transporter Type 3Hif1a protein, mouseHomeodomain ProteinsHypoxia-Inducible Factor 1, alpha SubunitmTOR protein, mousePrrx1 protein, mouseSlc2a1 protein, mouseSlc2a3 protein, mouseTOR Serine-Threonine KinasesTransforming Growth Factor beta

Identifiers

PMID39772668
PMCPMC11708888

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.