ArticleJournal of the American Chemical Society2025
Deacylative Homolysis of Ketone C(sp
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
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Who cites it
5 citing papers in PubMed.
- Carbocycle editing of ketones proceeds via a radical-mediated bidirectional C-C bond cleavage/coupling strategy.Nature communications · 2026Article
- Article
- Cross-ketone deacylative coupling via oxidative SNature communications · 2026Article
- Carbonyl-to-sulfur swap enabled by sequential double carbon-carbon bond activation.Science (New York, N.Y.) · 2025Article
- Synthesis through C(spAccounts of chemical research · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The homolytic cleavage of C-C bonds adjacent to specific functional groups has lately emerged as a versatile approach for molecular diversification. Despite the ubiquity and synthetic utility of ketones, radical fragmentation of their α-C-C bonds has proven to be a formidable challenge. Here, we present a broadly applicable deacylative strategy designed to homolytically cleave aliphatic ketones of various complexities, including transformations of cycloalkanones into carboxylic acids tethered to C-centered free radicals that can be engaged in diverse radical-based processes. The method involves ketone activation through treatment with hydrogen peroxide, yielding
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Registered trials
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