Evidence map›Paper›PMID 39772233›Full record

ArticleViruses2024

Discovery of Potent Dengue Virus NS2B-NS3 Protease Inhibitors Among Glycyrrhizic Acid Conjugates with Amino Acids and Dipeptides Esters.

Yu-Feng Lin, Hsueh-Chou Lai, Chen-Sheng Lin, Ping-Yi Hung, Ju-Ying Kan, Shih-Wen Chiu, Chih-Hao Lu, Svetlana F Petrova, Lidia Baltina, Cheng-Wen Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yu-Feng LinDepartment of Medical Laboratory Science and Biotechnology, Asia University, Taichung 41354, Taiwan.ORCID 0000-0003-1998-3310
Hsueh-Chou LaiDivision of Hepato-Gastroenterology, Department of Internal Medicine, China Medical University Hospital, Taichung 404327, Taiwan.
Chen-Sheng LinDivision of Gastroenterology, Kuang Tien General Hospital, Taichung 433401, Taiwan.
Ping-Yi HungDepartment of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404328, Taiwan.
Ju-Ying KanDepartment of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404328, Taiwan.
Shih-Wen ChiuInstitute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan.
Chih-Hao LuInstitute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan.ORCID 0000-0002-8363-6244
Svetlana F PetrovaUfa Institute of Chemistry, Ufa Federal Research Centre of RAS, Ufa 450054, Russia.ORCID 0000-0003-1406-0293
Lidia BaltinaUfa Institute of Chemistry, Ufa Federal Research Centre of RAS, Ufa 450054, Russia.ORCID 0000-0002-6291-5260
Cheng-Wen LinDepartment of Medical Laboratory Science and Biotechnology, Asia University, Taichung 41354, Taiwan.ORCID 0000-0003-0165-2652

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated a library of known and novel glycyrrhizic acid (GL) conjugates with amino acids and dipeptide esters, as inhibitors of the DENV NS2B-NS3 protease. We utilized docking algorithms to evaluate the interactions of these GL derivatives with key residues (His51, Asp75, Ser135, and Gly153) within 10 Å of the DENV-2 NS2B-NS3 protease binding pocket (PDB ID: 2FOM). It was found that compounds

Indexed as

Amino AcidsAntiviral AgentsDengue VirusDipeptidesEstersGlycyrrhizic AcidMolecular Docking SimulationProtease InhibitorsSerine EndopeptidasesViral Nonstructural ProteinsAnimalsBinding SitesDrug DiscoveryHumansViral ProteasesAmino AcidsAntiviral AgentsDipeptidesEstersGlycyrrhizic Acidnonstructural protein 2B, Dengue virusNS2B protein, flavivirusNS3 protease, dengue virusProtease InhibitorsSerine EndopeptidasesViral Nonstructural ProteinsViral Proteasesamino acidsantiviral activityconjugatesdengue virus type 2dipeptidesglycyrrhizic acidNS2B-NS3 proteasesynthesis

Identifiers

PMID39772233
PMCPMC11680386

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.