Evidence map›Paper›PMID 39772191›Full record

ArticleViruses2024

Findings from a Project Which Established Hepatitis C Point-of-Care Testing and Linkage to Care at a Homelessness Service in Adelaide, Australia, 2021-2022.

Erin M McCartney, Joshua Dawe, Lucy Ralton, Jeffrey Stewart, Jacqueline A Richmond, Alan Wigg, Victoria Cock, Edmund Y Tse, Tom Rees, David Shaw and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Erin M McCartneyInfectious Diseases Department, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide 5000, Australia.ORCID 0009-0001-4436-4151
Joshua DaweBristol Doctoral College, Bristol Medical School, Bristol BS8 2PN, UK.ORCID 0000-0002-3227-9849
Lucy RaltonInfectious Diseases Department, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide 5000, Australia.
Jeffrey StewartInfectious Disease Department, The Queen Elizabeth Hospital, Central Adelaide Local Health Network, Adelaide 5000, Australia.
Jacqueline A RichmondDisease Elimination, Burnet Institute, Melbourne 3004, Australia.
Alan WiggHepatology and Liver Transplantation Medicine Unit, Southern Adelaide Local Health Network, Adelaide 5042, Australia.
Victoria CockDrug and Alcohol Services, Glenside 5065, Australia.ORCID 0000-0002-2014-5077
Edmund Y TseGastroenterology & Hepatology Department, Royal Adelaide Hospital, Adelaide 5000, Australia.ORCID 0000-0003-0643-3926
Tom ReesCommunicable Disease Control Branch, SA Health, Adelaide 5000, Australia.
David ShawInfectious Diseases Department, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide 5000, Australia.ORCID 0000-0002-9359-050X
Catherine FergusonInfectious Diseases Department, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide 5000, Australia.

Funding

Gilead Sciences (Australia) Gilead Research Fellowship
6 · The paper itself

Abstract

backgroundPoint-of-care hepatitis C virus (HCV) testing streamlines testing and treatment pathways. In this study, we established an HCV model of care in a homelessness service by offering antibody and RNA point-of-care testing.

methodsA nurse and peer-led HCV model of care with peer support were implemented between November 2021 and April 2022 at a homelessness service in Adelaide, Australia. All clients of the service were eligible to participate. Clients were offered an initial antibody point-of-care test, and antibody positive clients were immediately offered RNA point-of-care testing. Clients who tested RNA positive were linked to a viral hepatitis nurse for treatment.

resultsA total of 230 clients received an HCV antibody point-of-care test, of which 68 (30%) were antibody positive and 11 (5%) were RNA positive. Of these, seven (64%) clients successfully completed treatment and five (45%) received a sustained virological response (SVR) test to confirm cure.

conclusionsWe successfully established HCV testing and a treatment pathway at a homelessness service using HCV antibody and RNA point-of-care testing. The high testing uptake underscores the utility of HCV point-of-care testing when establishing HCV testing and treatment pathways. The low RNA positivity suggests that an initial HCV antibody test was cost-effective, and the four clients diagnosed with chronic HCV who were lost to follow-up indicate a need for enhanced treatment support.

Indexed as

HepacivirusHepatitis CIll-Housed PersonsPoint-of-Care TestingAdultAustraliaFemaleHepatitis C AntibodiesHumansMaleMiddle AgedRNA, ViralSustained Virologic ResponseHepatitis C AntibodiesRNA, Viralhepatitis C virushomelessnesspeople who inject drugspoint-of-care testing

Identifiers

PMID39772191
PMCPMC11680382

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.