Evidence map›Paper›PMID 39772179›Full record

ArticleViruses2024

Case of Fatal Hepatitis Related to HEV-3 Infection in Central Italy.

Monica Borghi, Alessandro Graziani, Daniele Marini, Elisabetta Madonna, Umbertina Villano, Elisabetta Suffredini, Teresa Vicenza, Elida Mataj, Roberto Bruni, Anna Rita Ciccaglione and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Monica BorghiIstituto Zooprofilattico Sperimentale dell'Umbria e delle Marche, 06126 Perugia, Italy.ORCID 0000-0002-6337-5999
Alessandro GrazianiMicrobiology and Clinical Microbiology Section, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.ORCID 0000-0002-7833-3425
Daniele MariniMicrobiology Unit, Santa Maria della Misericordia Hospital, 06132 Perugia, Italy.
Elisabetta MadonnaDepartment of Infectious Diseases, Unit of Viral Hepatitis and Oncovirus and Retrovirus Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.
Umbertina VillanoDepartment of Infectious Diseases, Unit of Viral Hepatitis and Oncovirus and Retrovirus Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0001-5236-041X
Elisabetta SuffrediniDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0001-7605-0539
Teresa VicenzaDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-9524-8476
Elida MatajInstitute of Public Health (ISHP), 1000 Tirana, Albania.
Roberto BruniDepartment of Infectious Diseases, Unit of Viral Hepatitis and Oncovirus and Retrovirus Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-3035-5510
Anna Rita CiccaglioneDepartment of Infectious Diseases, Unit of Viral Hepatitis and Oncovirus and Retrovirus Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.
Barbara CamilloniMicrobiology and Clinical Microbiology Section, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.ORCID 0000-0003-2198-0127
Silvia BozzaMicrobiology and Clinical Microbiology Section, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis E virus (HEV) is a global health problem, causing an estimated 20 million infections annually. Thus, the management of HEV requires special consideration. In developed countries, hepatitis E is mainly recognized as a foodborne disease (mainly transmitted via undercooked meat consumption) that is generally caused by genotype 3 and 4 circulating in various animals, including pigs and wild boars. The current absence of officially recognized protocols for the analysis of HEV in foods and the lack of awareness of this disease among healthcare workers, together with the high percentage of asymptomatic cases, make HEV infection highly underestimated. Most HEV-3 infections in immunocompetent individuals are self-limited. Nevertheless, the possibility of serious forms of liver disease, especially in patients with co-morbidities, should be considered because it can lead to a fatal outcome. Here, we report a case of fatal hepatitis related to HEV-3 infection in a 67-year-old male patient with underlying chronic liver disease (CLD) and living in a region where a high prevalence and genetic heterogeneity of HEV-3 in wild boar has been recently demonstrated. Our case report describes the interdisciplinary approach used (from the diagnosis to the virus phylogenetic characterization) in order to improve epidemiologic HEV surveillance in central Italy.

Indexed as

GenotypeHepatitis EHepatitis E virusPhylogenyAgedAnimalsFatal OutcomeHumansItalyMaleSus scrofaSwinefoodborne diseasegenotype 3hepatitis E virusphylogenetic analysesviral hepatitis

Identifiers

PMID39772179
PMCPMC11680277

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.