Evidence map›Paper›PMID 39772170›Full record

ArticleViruses2024

Emerging SARS-CoV-2 Variants in Uganda in the Era of COVID-19 Vaccination.

Nicholas Bbosa, Ronald Kiiza, Alfred Ssekagiri, Hamidah Suubi Namagembe, Stella Esther Nabirye, Danstan Kabuuka, Cleophous Rwankindo, Annet Kisakye, Yonas T Woldemariam, Sylvia Kusemererwa and 14 more

Abstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Nicholas BbosaMRC/UVRI & LSHTM Uganda Research Unit, Entebbe 256, Uganda.ORCID 0000-0003-1280-675X
Ronald KiizaMRC/UVRI & LSHTM Uganda Research Unit, Entebbe 256, Uganda.
Alfred SsekagiriUganda Virus Research Institute, Entebbe 256, Uganda.ORCID 0000-0002-6549-3550
Hamidah Suubi NamagembeMRC/UVRI & LSHTM Uganda Research Unit, Entebbe 256, Uganda.
Stella Esther NabiryeUganda Virus Research Institute, Entebbe 256, Uganda.
Danstan KabuukaUganda Virus Research Institute, Entebbe 256, Uganda.
Cleophous RwankindoUganda Virus Research Institute, Entebbe 256, Uganda.ORCID 0009-0007-5630-2146
Annet KisakyeWorld Health Organization (WHO) Country Office, Kampala 256, Uganda.ORCID 0000-0003-4911-591X
Yonas T WoldemariamWorld Health Organization (WHO) Country Office, Kampala 256, Uganda.
Sylvia KusemererwaMRC/UVRI & LSHTM Uganda Research Unit, Entebbe 256, Uganda.ORCID 0000-0002-1390-109X
Terry A OngariaMRC/UVRI & LSHTM Uganda Research Unit, Entebbe 256, Uganda.ORCID 0009-0002-9885-2107
Ayoub KakandeMRC/UVRI & LSHTM Uganda Research Unit, Entebbe 256, Uganda.
Andrew AbaasaMRC/UVRI & LSHTM Uganda Research Unit, Entebbe 256, Uganda.
Geofrey KimbugweMRC/UVRI & LSHTM Uganda Research Unit, Entebbe 256, Uganda.
Henry Kyobe BosaMinistry of Health, Kampala 256, Uganda.ORCID 0000-0001-6593-8727
Alfred DriwaleMinistry of Health, Kampala 256, Uganda.
Jason M MwendaThe African Region Monitoring Vaccine Effectiveness (AFRO-MoVE) Network, World Health Organization-Regional Office for Africa, Brazzaville 99324, Congo.
Archibald K WorwuiThe African Region Monitoring Vaccine Effectiveness (AFRO-MoVE) Network, World Health Organization-Regional Office for Africa, Brazzaville 99324, Congo.
James HumphreysEpiconcept Company, 75011 Paris, France.ORCID 0009-0004-3789-8309
Sandra CohuetEpiconcept Company, 75011 Paris, France.ORCID 0009-0001-1049-6973
Alison M ElliottMRC/UVRI & LSHTM Uganda Research Unit, Entebbe 256, Uganda.
Eugene RuzagiraMRC/UVRI & LSHTM Uganda Research Unit, Entebbe 256, Uganda.ORCID 0000-0002-7291-1693
Pontiano KaleebuMRC/UVRI & LSHTM Uganda Research Unit, Entebbe 256, Uganda.
Deogratius SsemwangaMRC/UVRI & LSHTM Uganda Research Unit, Entebbe 256, Uganda.ORCID 0000-0001-9675-4234

Funding

World Health Organization 001World Health Organization (WHO) and Bill & Melinda Gates Foundation 2022/1308549-0
6 · The paper itself

Abstract

The emergence of SARS-CoV-2 variants has heightened concerns about vaccine efficacy, posing challenges in controlling the spread of COVID-19. As part of the COVID-19 Vaccine Effectiveness and Variants (COVVAR) study in Uganda, this study aimed to genotype and characterize SARS-CoV-2 variants in patients with COVID-19-like symptoms who tested positive on a real-time PCR. Amplicon deep sequencing was performed on 163 oropharyngeal/nasopharyngeal swabs collected from symptomatic patients. Genome assembly, lineage classification and phylogenetic analysis was performed using the Edge Bioinformatics pipeline version 2.4.0, Pangolin version 4.3.1 and iqtree version 2.3.6 software respectively. Of the 163 deep sequences analyzed between April 2023 and March 2024, the most common were XBB.1 lineages and sublineages (113, 69.3%), followed by JN.1* (12, 7.4%), XBB.2* (11, 6.7%) and FL* (11, 6.7%), EG* (7, 4.3%), others (BQ.1.1, FY.4.1, FY.4.1.2, GY.2.1, HK.27.1) (5, 3.1%) and CM* (4, 2.5%). XBB.1* dominated from April to July 2023; thereafter, other variants, including JN.1* were increasingly detected. There was no statistically significant association between vaccine status and lineage assignment (Fisher's exact test,

Indexed as

COVID-19COVID-19 VaccinesPhylogenySARS-CoV-2AdultFemaleGenome, ViralHigh-Throughput Nucleotide SequencingHumansMaleMutationUgandaVaccinationCOVID-19 VaccinesCOVID-19next-generation sequencingomicronSARS-CoV-2vaccinevariants

Identifiers

PMID39772170
PMCPMC11680199

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.