Evidence map›Paper›PMID 39772163›Full record

ArticleViruses2024

Predictive Efficacy of Dual Therapies Combining Integrase Strand Transfer Inhibitors with Second-Generation Non-Nucleoside Reverse Transcriptase Inhibitors Following HIV-1 Treatment Failure in Cameroon: Implications for the Use of a Long-Acting Therapeutic Strategy in Low- and Middle-Income Countries.

Davy-Hyacinthe Gouissi Anguechia, Yagai Bouba, Ezechiel Ngoufack Jagni Semengue, Aude Christelle Ka'e, Désiré Takou, Collins Ambe Chenwi, Grace Beloumou, Alex Durand Nka, Ulrich Roland Basseck Wome, Maria Mercedes Santoro and 10 more

Abstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Davy-Hyacinthe Gouissi AnguechiaChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.ORCID 0009-0005-7377-1652
Yagai BoubaChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.ORCID 0000-0002-4187-683X
Ezechiel Ngoufack Jagni SemengueChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.
Aude Christelle Ka'eChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.ORCID 0000-0002-2381-4299
Désiré TakouChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.
Collins Ambe ChenwiChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.ORCID 0000-0002-6749-1436
Grace BeloumouChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.
Alex Durand NkaChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.
Ulrich Roland Basseck WomeChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.
Maria Mercedes SantoroDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0002-6228-1114
Francesca Ceccherini-SilbersteinDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Adawaye ChattéProject Management Unit, Ministry of Health, N'djamena P.O. Box 548, Chad.
Carla MontesanoDepartment of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy.
Giulia CappelliNational Research Council, 00185 Rome, Italy.ORCID 0000-0002-5353-5549
Vittorio ColizziChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.
Alexis NdjoloChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.
Dora MbanyaFaculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé P.O. Box 337, Cameroon.
Nicaise NdembiAfrica Centres for Disease Control and Prevention, Addis Ababa P.O. Box 3243, Ethiopia.
Carlo-Federico PernoChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.
Joseph FokamChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.ORCID 0000-0002-1501-2763

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dual therapies (DT) combining integrase strand transfer inhibitors (INSTIs) with second-generation non-nucleoside reverse transcriptase inhibitors (2nd-Gen-NNRTIs) offer new possibilities for HIV treatment to improve adherence. However, drug resistance associated mutations (RAMs) to prior antiretrovirals may jeopardize the efficacy of DT. We herein describe the predicted efficacy of DT combining INSTIs + 2nd-Gen-NNRTI following treatment failure among Cameroonian patients. We genotyped the HIV-1

Indexed as

Drug Resistance, ViralHeterocyclic Compounds, 3-RingHIV-1HIV InfectionsHIV Integrase InhibitorsReverse Transcriptase InhibitorsTreatment FailureAdultAmidesAnti-HIV AgentsCameroonDeveloping CountriesDiketopiperazinesDolutegravirDrug Therapy, CombinationFemaleAmidesAnti-HIV AgentsbictegravircabotegravirDiketopiperazinesDolutegraviretravirineHeterocyclic Compounds, 3-RingHeterocyclic Compounds, 4 or More RingsHIV Integrase InhibitorsNitrilesOxazinesPiperazinesPyridazinesPyridonesPyrimidinesReverse Transcriptase InhibitorsRilpivirineCameroondual therapiesHIV-1integrase strand transfer inhibitornon-nucleosides reverse transcriptase inhibitorspredictive efficacy

Identifiers

PMID39772163
PMCPMC11680099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.