Evidence map›Paper›PMID 39772088›Full record

ArticleVaccines2024

Samara Sousa de Pinho, Maria da Conceição Viana Invenção, Anna Jéssica Duarte Silva, Larissa Silva de Macêdo, Benigno Cristofer Flores Espinoza, Lígia Rosa Sales Leal, Marco Antonio Turiah Machado da Gama, Ingrid Andrêssa de Moura, Micaela Evellin Dos Santos Silva, Débora Vitória Santos de Souza and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Samara Sousa de PinhoLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0001-5576-3652
Maria da Conceição Viana InvençãoLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0001-9360-1275
Anna Jéssica Duarte SilvaLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0002-8341-7877
Larissa Silva de MacêdoLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0003-1660-4901
Benigno Cristofer Flores EspinozaLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0001-8185-9818
Lígia Rosa Sales LealLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.
Marco Antonio Turiah Machado da GamaLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0001-9739-3100
Ingrid Andrêssa de MouraLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0002-0715-8674
Micaela Evellin Dos Santos SilvaLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0009-0001-0842-4938
Débora Vitória Santos de SouzaLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.
Marina Linhares LaraLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.
Julia Nayane Soares Azevedo AlvesLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.
Antonio Carlos de FreitasLaboratory of Molecular Studies and Experimental Therapy-LEMTE, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0002-4957-9549

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq N° 31/2022, grant number 440315/2022-0Fundação de Amparo à Ciência e Tecnologia de Pernambuco (FACEPE) IBPG-0954-2.00/22Fundação de Amparo à Ciência e Tecnologia de Pernambuco (FACEPE) IBPG-1652-2.00/21Programa de Apoio à Fixação de Jovens Doutores em Pernambuco APQ-1482-2.02/22
6 · The paper itself

Abstract

BACKGROUND/

objectivesDNA vaccines are rapidly produced and adaptable to different pathogens, but they face considerable challenges regarding stability and delivery to the cellular target. Thus, effective delivery methods are essential for the success of these vaccines. Here, we evaluated the efficacy of capsules derived from the cell wall of the yeast

methodsThe capsules were extracted from the yeast

resultsThe microscopy results indicated that the macrophages successfully phagocytosed the capsules. Among the protocols tested for encapsulation, the one with 2% polyethylenimine for internalization showed the highest efficiency, with an encapsulation rate above 80%. However, the vaccine capsules obtained with the protocol that used 5% NaCl showed better thermal stability and encapsulation efficiency above 63% without induction of cell viability loss in HEK 293T.

conclusionsWe successfully described a vaccine delivery system using yeast capsules derived from

Indexed as

glucan particlenucleic acidsyeast cell wall

Identifiers

PMID39772088
PMCPMC11728682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.