Evidence map›Paper›PMID 39771587›Full record

ArticlePharmaceutics2024

Gemcitabine-Loaded Microbeads for Transarterial Chemoembolization of Rabbit Renal Tumor Monitored by

Xiaoli Zhang, Tingting Li, Jindong Tong, Meihong Zhou, Zi Wang, Xingdang Liu, Wei Lu, Jingjing Lou, Qingtong Yi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoli ZhangDepartment of Urology and Department of Nuclear Medicine, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.
Tingting LiQuzhou Fudan Institute, Quzhou 324002, China.
Jindong TongDepartment of Vascular Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center & Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling, Shanghai 201399, China.
Meihong ZhouDepartment of Urology and Department of Nuclear Medicine, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.
Zi WangDepartment of Urology and Department of Nuclear Medicine, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.
Xingdang LiuDepartment of Urology and Department of Nuclear Medicine, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.
Wei LuQuzhou Fudan Institute, Quzhou 324002, China.ORCID 0000-0002-1333-0274
Jingjing LouDepartment of Urology and Department of Nuclear Medicine, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.
Qingtong YiDepartment of Urology and Department of Nuclear Medicine, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.ORCID 0000-0001-7167-3024

Funding

Clinical research program of Health Industry of Shanghai Municipal Commission of Health 202150002Medical Engineering Jiont Fund of Fudan University yg2022-34Multidisciplinary Team for Urinary Incontinence and Pelvic Floor Diseases of Shanghai Pudong Hospital MDT2021-06Natural Science Foundation of China 82272042, 81991493, 82471857Science and Technology Development Fund of Shanghai Pudong New Area PKJ2019-Y29Shanghai Municipal Health Commission 2022XD045
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe purpose of this study was to develop the gemcitabine-loaded drug-eluting beads (G-DEBs) for transarterial chemoembolization (TACE) in rabbit renal tumors and to evaluate their antitumor effect using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography/X-ray computed tomography (

methodsDEBs were prepared by polyvinyl alcohol-based macromer crosslinked with

resultsThe average particle size of the microspheres was 58.06 ± 0.50 µm, and the polydisperse index was 0.26 ± 0.002. The maximum loading rate of G-DEBs was 18.09 ± 0.35%, with almost 100% encapsulation efficiency. Within 24 h, GEM was eluted from G-DEBs rapidly and completely, and more than 20% was released in different media. DSA illustrated that G-DEBs were delivered to rabbit renal tumors. Compared with the untreated control group with increased tumor volume and intense

conclusionsOur results demonstrated that G-DEBs are effective in TACE treatment of rabbit VX2 renal tumors, and

Indexed as

2-deoxy-2-[(18)F]fluoro-D-glucose (18F-FDG)drug-eluting beads (DEBs)gemcitabinepositron emission tomography/X-ray computed tomography (PET/CT)renal cell carcinoma (RCC)transarterial chemoembolization (TACE)

Identifiers

PMID39771587
PMCPMC11678015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.